| 泰乐菌素注射液的毒性试验研究 |
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| 引用本文： | 饶勇,曾子建,古淑英,李逐波,陈力.泰乐菌素注射液的毒性试验研究[J].西南农业大学学报(社会科学版),1997(3). |
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| 作者姓名： | 饶勇 曾子建 古淑英 李逐波 陈力 |
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| 作者单位： | 四川畜牧兽医学院动物医学系
(饶勇，曾子建，古淑英，李逐波)，四川畜牧兽医学院动物医学系(陈力) |
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| 摘 要： | 为提供泰乐菌素注射液的毒理学评价资料.本试验采用改良Karber法测定小鼠LD以剂量递增法测定小鼠蓄积性和耐受性。分别以剂量230、90、40 mg/kg为3个试验组,设阴性和阳性组对照进行小鼠骨髓微核试验;分别以剂量380、190、90mg/kg为3个剂量组,设阴性和阳性对照组进行小鼠精子畸形试验。结果表明:其LD50为448.75 mg/kg,蓄积系数大于5.3,无明显蓄积毒性和耐受性(P>0.05),小鼠骨髓微核试验和精子畸形试验结果,均为阴性。
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| 关 键 词： | 泰乐菌素注射液 LD_(50) 蓄积性毒性试验 耐受性试验 骨髓微核试验 精子畸形试验 |
STUDY ON THE TOXICITY TESTS OF TYLOSIN INJECTION |
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| Rao Yong Zheng Zijian Gu Shuyeng.STUDY ON THE TOXICITY TESTS OF TYLOSIN INJECTION[J].Journal of Southwest Agricultural University:Social Science Edition,1997(3). |
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| Authors: | Rao Yong Zheng Zijian Gu Shuyeng |
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| Institution: | Rao Yong Zheng Zijian Gu Shuyeng |
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| Abstract: | In order to provide some scientific data for safe toxicological evalutation of Ty-losin injection, this paper determines LD50by improved Karber method, accumulative toxicity test and tolerance test by progressive dose increase method,bone marrow micronucleus test with 3 experimental groups at dosage of 230,90 or 40 mg/kg respectively and positibve and negative control groups, spermatogenic malformation test with 3 experimental groups at dosage of 380,190 or 90 mg/kg/day respectively and positive and negative control groups. Experimental animals used in these 5 tests are mice. The data are 448. 75 mg/kg(LD50) and over 5. 3 (accumulative coefficient). The other 3 resulrs are all negative. |
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| Keywords: | Tylosin injection LD50 Accumulative toxicity experiment Tolerance test Bone marrow micronucleus test Spermatogenic malformation test |
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