| 新能量状态下抗肿瘤光敏剂的研究 |
| |
| 引用本文： | 李翀,卓先勤. 新能量状态下抗肿瘤光敏剂的研究[J]. 琼州学院学报, 2012, 19(2): 26-28 |
| |
| 作者姓名： | 李翀 卓先勤 |
| |
| 作者单位： | 1. 三亚市人民医院重症医学科,海南三亚,572000
2. 琼州学院理工学院,海南三亚,572022 |
| |
| 摘 要： | 研究光动力疗法（photodynamic therapy,PDT）治疗肿瘤的机制.方法：建立裸鼠胰腺癌模型,以血卟啉衍生物作为光敏剂,测定PDT治疗后,肿瘤组织内脂质过氧化产物丙二醛（MDA）的含量,并采用免疫组化LSAB法,对肿瘤区血管损伤状况进行研究.
|
| 关 键 词： | 肿瘤 光动力治疗 制备 |
Studies on Singlet Oxygen Caused by New State of Photosensitizer |
| |
| LI Chong,ZHUO Xian-qin. Studies on Singlet Oxygen Caused by New State of Photosensitizer[J]. Journal of Qiongzhou University, 2012, 19(2): 26-28 |
| |
| Authors: | LI Chong ZHUO Xian-qin |
| |
| Affiliation: | 1.Intensive Care Unit,People’s Hospital of Sanya City,Sanya Hainan 572000,China; 2.College of Science and Engineering,Qiongzhou University,Sanya Hainan 572022,China) |
| |
| Abstract: | To study the mechanism of photodynamic therapy(PDT) to neoplasm.Methods : developing the nude mice animal model of pancreatic cancer,the photosensitizers HPD was given by the intraperitoneal injection,After the therapy the level of MDA in different groups was analysed and factor-Ⅷwas used in the immunohistochemical staining to study the vessel change.Results;The level of MDA in the PDT group was higher than that of the controls,immunohistochemical staining showed PDT can make injury to vessel endothelial cell and destruct vessel structure.PDT can induce injuries of neoplasm,oxidation and vascular injury is important way to exert function. |
| |
| Keywords: | Neoplasm photodynamic therapy preparation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
