Testing non-inferiority and superiority for two endpoints for several treatments with a control |
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Authors: | Lawrence John |
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Institution: | US Food and Drug Administration, Silver Spring, MD 20993-002, USA. John.Lawrence@fda.hhs.gov |
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Abstract: | Some multiple comparison procedures are described for multiple armed studies. The procedures are appropriate for testing all hypotheses for comparing two endpoints and multiple test arms to a single control group, for example three different fixed doses compared to a placebo. The procedure assumes that among the two endpoints, one is designated as a primary endpoint such that for a given treatment arm, no hypothesis for the secondary endpoint can be rejected unless the hypothesis for the primary endpoint was rejected. The procedures described control the family-wise error rate in the strong sense at a specified level α. |
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Keywords: | multiple comparisons with a control Dunnett's test Gatekeeping tests |
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