Estimation and Classification of BOLD Responses Over Multiple Trials

In this article, we model functional magnetic resonance imaging (fMRI) data for event-related experiment data using a fourth degree spline to fit voxel specific blood oxygenation level-dependent (BOLD) responses. The data are preprocessed for removing long term temporal components such as drifts using wavelet approximations. The spatial dependence is incorporated in the data by the application of 3D Gaussian spatial filter. The methodology assigns an activation score to each trial based on the voxel specific characteristics of the response curve. The proposed procedure has a capability of being fully automated and it produces activation images based on overall scores assigned to each voxel. The methodology is illustrated on real data from an event-related design experiment of visually guided saccades (VGS).