A backward procedure for change-point detection with applications to copy number variation detection |
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Authors: | Seung Jun Shin Yichao Wu Ning Hao |
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Institution: | 1. Department of Statistics, Korea University, Seoul, South Korea;2. Department of Mathematics, Statistics, and Computer Science, The University of Illinois at Chicago, Chicago, IL, U.S.A.;3. Department of Mathematics, The University of Arizona, Tuscon, AZ, U.S.A. |
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Abstract: | Change-point detection regains much attention recently for analyzing array or sequencing data for copy number variation (CNV) detection. In such applications, the true signals are typically very short and buried in the long data sequence, which makes it challenging to identify the variations efficiently and accurately. In this article, we propose a new change-point detection method, a backward procedure, which is not only fast and simple enough to exploit high-dimensional data but also performs very well for detecting short signals. Although motivated by CNV detection, the backward procedure is generally applicable to assorted change-point problems that arise in a variety of scientific applications. It is illustrated by both simulated and real CNV data that the backward detection has clear advantages over other competing methods, especially when the true signal is short. The Canadian Journal of Statistics 48: 366–385; 2020 © 2020 Statistical Society of Canada |
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Keywords: | Backward detection copy number variation mean change-point model multiple change points Short signal |
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