Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study |
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| Authors: | Rosita A. Condorelli Aldo E. Calogero Maurizio Di Mauro Laura M. Mongioì Giorgio I. Russo Giuseppe Morgia |
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| Affiliation: | 1. Department of Clinical and Experimental Medicine – CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes), University of Catania, Catania, Italy,;2. CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes), University of Catania, Catania, Italy, and;3. Department of Urology, University of Catania, Catania, Italy |
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| Abstract: | Purpose: To investigate a possible relation between penile Doppler ultrasound examination (PDUE) parameters and efficacy of chronic therapy with tadalafil (TAD) combined with a protocol of aerobic physical activity (PA) in patients with late onset hypogonadism (LOH). Methods: The study evaluated 30 patients consecutively enrolled with LOH and erectile dysfunction which present contraindication to hormonal replacement therapy for concomitant prostate disease. These patients were subjected to a combined protocol with phosphodiesterase V selective inhibitors (TAD 5?mg daily) and aerobic PA.Results: After three months, we observed significant improvements in erectile function [IIEF-5, median (IQR)?=?13.0 (7.0–18.0) versus 6.0 (5.0–6.75); p?p?Conclusion: PA in association with phosphodiesterase V inhibitors could compensate the effects of hypogonadism on erectile function and facilitate the clinical response to these drugs even in the absence of adequate serum concentrations of total testosterone. |
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| Keywords: | Erectile dysfunction penile Doppler PDE5i LOH physical activity |
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