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Survival Analysis For A Sequenced Clinical Trial With Covariates |
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| Authors: | K L Q Read A A Noura R R Harris |
| Affiliation: | Department of Mathematical Statistics and Operational Research , University of Exeter , Exeter , UK |
| Abstract: | In this paper we discuss the survival analysis for a clinical trial in which treatment categories and general prognostic data are realised at different stages during a patient's survival time. In the light of possible strategies for the parsimonious modelling of such data, a corresponding sequence of illustrative analyses is presented. Detailed results are given for a weighted least squares analysis and these generally agree with those obtained by maximum likelihood. |
| Keywords: | Survival analysis categorical data complementary log-log transformation time-related covariates parsimonious modelling weighted least squares maximum likelihood |