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Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly |
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| Authors: | Luis Miguel Gutiérrez-Robledo José Alberto Ávila-Funes Hélène Amieva Céline Meillon José Luis Acosta Ana Patricia Navarrete-Reyes |
| Institution: | 1. Instituto Nacional de Geriatría, México, D.F., Mexico,;2. Departamento de Geriatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico,;3. Centre de recherche Inserm, U897, Bordeaux, France;4. Univ Victor Segalen Bordeaux 2, Bordeaux, France,;5. Centre de recherche Inserm, U897, Bordeaux, France;6. Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico,;7. Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR)-Unidad Sinaloa, Sinaloa, Mexico, and;8. Departamento de Geriatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico, |
| Abstract: | Objective: Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.Methods: Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the “Coyoacán cohort” were included. 25(OH)-vitamin D assay and frailty status were measured.Results: Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have lower Mini-Mental State Examination score (p?=?0.015), more disability for instrumental activities of daily living (p?p?p?Conclusion: These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels. |
| Keywords: | Frailty syndrome vitamin D older people |