A 3-parameter Gompertz distribution for survival data with competing risks,with an application to breast cancer data |
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| Authors: | S R Haile J-H Jeong X Chen Y Cheng |
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| Institution: | 1. Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland;2. Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA;3. Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA;4. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA |
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| Abstract: | The cumulative incidence function is of great importance in the analysis of survival data when competing risks are present. Parametric modeling of such functions, which are by nature improper, suggests the use of improper distributions. One frequently used improper distribution is that of Gompertz, which captures only monotone hazard shapes. In some applications, however, subdistribution hazard estimates have been observed with unimodal shapes. An extension to the Gompertz distribution is presented which can capture unimodal as well as monotone hazard shapes. Important properties of the proposed distribution are discussed, and the proposed distribution is used to analyze survival data from a breast cancer clinical trial. |
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| Keywords: | Competing risks cumulative incidence function improper distribution subdistribution hazards parametric modeling survival analysis |
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