Fitting Weibull duration models with random effects |
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Authors: | Carl Morris Cindy Christiansen |
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Institution: | (1) Department of Statistics, Harvard University, 02138 Cambridge, MA;(2) Department of Ambulatory Care and Prevention, Harvard Medical School, 126 Brookline Ave, Suite 200, 02215 Boston, MA |
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Abstract: | Duration time models often should include correlated failure times, due to clustered data. These random effects hierarchical models sometimes are called frailty models when used for survival analyses. The data analyzed here involve such correlations because patient level outcomes (the times until graft failure following kidney transplantation) are observed, but patients are clustered in different transplant centers. We describe fitting such models by combining two kinds of software, one for parametric survival regression models, and the other for doing Poisson regression in a hierarchical setting. The latter is implemented by using PRIMM (Poisson Regression and Interactive Multilevel Modeling) methods and software (Christiansen & Morris, 1994a). An illustrative example for profiling data is included withk=11 kidney transplant centers andN=412 patients. |
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Keywords: | EM frailty hierarchical models kidney transplants medical profiling parametric survival models PRIMM |
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