| 新型注射用利培酮微球的药效学研究 |
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| 引用本文： | 董秋菊,何杰,宫晓燕,于鹏飞,张方喜,杜广营,张剑钊,叶亮,田京伟.新型注射用利培酮微球的药效学研究[J].鲁东大学学报,2013(2):149-154,179. |
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| 作者姓名： | 董秋菊 何杰 宫晓燕 于鹏飞 张方喜 杜广营 张剑钊 叶亮 田京伟 |
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| 作者单位： | [1]烟台大学药学院,山东烟台264005 [2]山东绿叶制药有限公司长效和靶向制剂国家重点实验室,山东烟台264003 |
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| 基金项目： | 国家自然科学基金（81001661）;山东省中青年科学家科研奖励基金（BS2009SW）;国家重点基础研究项目（2012CB724003）. |
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| 摘 要： | 制备了新型注射用利培酮微球(NRMI),采用5-HTP诱导大鼠甩头和APO诱导大鼠过度活动模型,与商品注射用利培酮微球(恒德)进行对比,评价了NRMI的药效优势.结果显示,NRMI和恒德对大鼠甩头和过度活动均有抑制作用,NRMI给药后立即起效,维持约3～4周,而恒德给药3周后起效,维持约2周.表明NR-MI起效时间早于恒德,且维持时间长于恒德,如用于临床治疗依从性可能优于恒德.
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| 关 键 词： | 精神分裂症 利培酮 NRMI 5-HTP APO |
Pharmacodynamic Study of Novel Risperidone Microspheres for Injection |
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| DONG Qiu-ju,HE Jie,GONG Xiao-yan,YU Peng-fei,ZHANG Fang-xi,DU Guang-ying,ZHANG Jian-zhao,YE Liang,TIAN Jing-wei.Pharmacodynamic Study of Novel Risperidone Microspheres for Injection[J].Ludong University Journal (Natural Science Edition),2013(2):149-154,179. |
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| Authors: | DONG Qiu-ju HE Jie GONG Xiao-yan YU Peng-fei ZHANG Fang-xi DU Guang-ying ZHANG Jian-zhao YE Liang TIAN Jing-wei |
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| Institution: | 1. School of Pharmacy, Yantai University, Yantai 264005, China;2. State Key Laboratory of Long-Acting and Targeting Drug Delivery System Shandong Luye Pharmaceutical Co Ltd, Yantai 264003, China) |
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| Abstract: | Head twitch induced by 5-HTP and hyperactivity induced by APO animal models were uesd to com- pare the pharmacodynamic advantages of novel risperidone microspheres for injection （NRMI） with those of Consta. The results showed that both NRMI and Consta could inhibite head twitch induced by 5-HTP and hyperactivity induced by APO. The effects of NRMI were shown immediately afer administration and could be sustained for 3 4 weeks, while the effects of Consta were shown 3 weeks afer administration and could be sustained for about 2 weeks. These results indicated that NRMI worked faster and longer than Consta. It would have a better compliance than Consta if used in clinical therapy. |
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| Keywords: | schizophrenia risperidone NRMI 5-HTP APO |
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