| 蛋白质二级结构序列片段的识别 |
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| 引用本文： | 胡秀珍,李前忠.蛋白质二级结构序列片段的识别[J].内蒙古工业大学学报,2007,26(4):246-251. |
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| 作者姓名： | 胡秀珍 李前忠 |
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| 作者单位： | 内蒙古工业大学理学院物理系，内蒙古大学理工学院物理系 呼和浩特010062，内蒙古大学理工学院物理系，呼和浩特010021，呼和浩特010021 |
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| 基金项目： | 国家自然科学基金资助项目30560039，内蒙古自然科学基金资助项目200508010509 |
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| 摘 要： | 识别蛋白质二级结构片段,实质上是从序列片段的水平上对二级结构进行预测.用离散量的方法,通过一系列的计算发现:选择氨基酸(20种氨基酸加一个空位)和其紧邻关联共同为参数,从N端截取固定长序列片段为6或7个连续氨基酸残基时,10交叉检验平均预测精度能达到75%~77%,jack-knife检验平均预测精度能达到72%;当固定长序列片段为9或10个连续氨基酸残基时,10交叉检验平均预测精度能达到82%~83%,jack-knife检验平均预测精度能达到74%~76%.
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| 关 键 词： | 离散量方法 蛋白质二级结构 序列片段 |
| 文章编号： | 1001-5167（2007）04-0246-06 |
| 收稿时间： | 2006-09-11 |
RECOGNITION OF SECONDARY STRUCTURE SEGMENTS OF PROTEINS |
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| HU Xiu-zhen,LI Qian-zhong.RECOGNITION OF SECONDARY STRUCTURE SEGMENTS OF PROTEINS[J].Journal of Inner Mongolia Polytechnic University(Social Sciences Edition),2007,26(4):246-251. |
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| Authors: | HU Xiu-zhen LI Qian-zhong |
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| Abstract: | The recognition of secondary structure segments of proteins is,in substance,a prediction of secondary structure at the level of segments.By use of the measure of diversity,a series of calculations are made.It is found that,with amino acid composition and dipeptide composition taken as parameters,in fixed-length sequence with 6 or 7 amino acids from N terminal,the average prediction accuracy of 10-cross validation test reaches 75%~77%,while with jack-knife test the average prediction accuracy is no more than 72%.In case the fixed-length sequence chosen contains 9 or 10 amino acids,the average prediction accuracy of 10-cross validation test will reach 82%,while with jack-knife test it will be 74%~76%. |
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| Keywords: | measure of diversity secondary structure of protein segment of sequence |
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