Tests for comparing a sequence of bernoulli random variables to a sequence of known probabilities

The problem of determining whether a sequence of observed Bernoulli variates is consistent with a hypothesized underlying sequence of known probabilities is considered. A family of asymptotically normal test statistics is proposed, members of which are shown to be asymptotically locally optimal against specific types of alternatives. For small samples, a skewness correction is shown to improve greatly the adequacy of the asymptotic approximations to the null distributions of the proposed test statistics. The application of testing for increased cancer risk in families is considered, and modifications to the test statistics which adjust for the method of family ascertainment are indicated