Assessing multiple endpoints with ordered alternatives |
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| Authors: | Kao-Tai Tsai James A Kozial |
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| Institution: | 1. Schering-Plough Corporation , Kenilworth, New Jersey, 07033;2. Research Institute of Scripps Clinic , La Jolla, California, 92037 |
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| Abstract: | Nonparametric approaches to the analysis of multiple endpoints in clinical studies can be of particular value when the endpoints are heterogeneous or distributional assumptions are suspect. We describe a multivariate Terpstra-Jonckheere U-statistic for assessing multiple endpoints with ordered alternatives, and illustrate its use with data arising from a recent clinical study. |
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| Keywords: | ordered alternatives multiple endpoints clinical trials multivariate U-statistics |
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