On the analysis of multivariate repeated measures designs

The relationship between the mixed-model analysis and multivariate approach to a repeated measures design with multiple responses is presented. It is shown that by taking the trace of the appropriate submatrix of the hypothesis (error) sums of squares and crossproducts (SSCP) matrix obtained from the multivariate approach, one can get the hypothesis (error) SSCP matrix for the mixed-model analysis. Thus, when analyzing data from a multivariate repeated measures design, it is advantageous to use the multivariate approach because the result of the mixed-model analysis can also be obtained without additional computation.