Caliper pair-matching on a continuous variable in case-control studies

The use of matched pairs has been criticized as being less efficient than estimators based on random samples. This paper compares the mean square error of an analysis of covariance estimator based on random samples with two estimators based on caliper matched pairs. The first of these is a simple mean difference estimator and the second a regression estimator suggested by Rubin (1973b). Under conditions which commonly occur in epidemiologic case-control studies, both of the matched pair estimators can have smaller mean square errors than analysis o f covariance estimator. When there is a weak relationship between the matching and response variate, the mean difference estimator has a lower mean square error than the regression estimator.