1. Dept. of Community Medicine , University of Pittsburgh , Cleft Palate Center Children's Hospital of Pittsburgh, Pittsburgh, PA, 15261;2. Dept. of Biostatistics , University of Pittsburgh , Pittsburgh, PA, 15261
Abstract:
The problem of analyzing and modeling incomplete longitudinal data arising from clinical and epidemiological studies are discussed, A method for handling arbitrarily missing observations under the intra class correlation structure and a polynomial model is developed. Explicit expressions for likelihood equations and information matrix for a second degree polynomial model are provided. The method is illustrated through an example.