Repeated confidence intervals and prediction intervals using stochastic curtailment |
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Authors: | Barry R. Davis Robert J. Hardy |
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Affiliation: | The University of Texas School of Public Health , 1200 Herman Pressler Street, Suite 801, Houston, Texas, 77030 |
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Abstract: | Jennlson and Turnbull (1984,1989) proposed procedures for repeated confidence intervals for parameters of interest In a clinical trial monitored with group sequential methods. These methods are extended for use with stochastic curtailment procedures for two samples in the estimation of differences of means, differences of proportions, odds ratios, and hazard ratios. Methods are described for constructing 1) confidence intervals for these estimates at repeated times In the course of a trial, and 2) prediction intervals for predicted estimates at the end of a trial. Specific examples from several clinical trials are presented. |
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Keywords: | Stochastic curtailment repeated confidence intervals |
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