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Group sequential designs using both type I and type II error probability spending functions |
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| Authors: | Myron N. Chang Irving K. Hwang Weichung J. Shin |
| Affiliation: | 1. Statistics Department , Univeisity of Florida , Gainesville, FL, 32611;2. Irring Consultive Group , PO Box 238, NJ, 07078 0258;3. Biostatistics and Research Data Systems , Merk Research Laboratories , Rahway, NJ, 07065 |
| Abstract: | We propose flexible group sequential designs using type I and type II error probability spending functions. The proposed designs preserve the overall significance level and power and allow the repeated testing to be perloimed at a flexible schedule. Computational methods are described. An example on a mega clinical trial is provided. |
| Keywords: | flexible group sequential designs error spending functions information times decision boundaries |