Risk Assessment of Nitrated Polycyclic Aromatic Hydrocarbons |
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| Authors: | L Möller I Lax U-B Torndal L C Eriksson |
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| Institution: | 1 Center for Nutrition and Toxicology, Karolinska Institute, NOVUM Research Park, S-141 57 Huddinge, Sweden.;2 Department of Hospital Physics, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden.;3 Department of Pathology, Karolinska Institute, Huddinge University Hospital, F58, S-141 86 Huddinge, Sweden. |
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| Abstract: | Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) constitute a group of substances formed during incomplete combustion. Sources include diesel vehicles, heating, smoking, certain types of food-processing, and incomplete combustion in general. 2-Nitrofluorene (NF) represents a model substance for the nitro-PAHs. An attempt has been made to estimate the lifetime human cancer risk due to background exposure to nitro-PAHs by two different models. The first model is based on genotoxic lesions produced by gamma-irradiation and the second model is based on an earlier published mega study (24,000 animals) on the carcinogenicity of the major metabolite of NF. Both models agreed well-representing a yearly human cancer risk in the range of 0.15–49 × 10−6 for an urban citizen. The weaknesses and strengths of the models are discussed. |
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| Keywords: | NF nitro-PAH γ-irraditation risk assessment |
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