| 气体抗溶剂法制备乙基纤维素微球过程的实验研究 |
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| 引用本文： | 陈岚,张岩,李保国,伍贻文,华泽钊,刘哲鹏,陆伟跃.气体抗溶剂法制备乙基纤维素微球过程的实验研究[J].上海理工大学学报(社会科学版),2004,26(2):121-125. |
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| 作者姓名： | 陈岚 张岩 李保国 伍贻文 华泽钊 刘哲鹏 陆伟跃 |
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| 作者单位： | [1]上海理工大学动力工程学院，上海200093 [2]复旦大学药学院，上海200032 |
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| 基金项目： | 国家自然科学基金 (5 9836 2 4 0 )，上海市教委重点学科建设项目共同资助 |
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| 摘 要： | 对超临界流体制粒中的气体抗溶剂(GAS)法进行了改进，并制备出了平均粒径为0．1～10μm乙基纤维素微球，同时对GAS过程的影响因素，进行了系统的实验研究．结果表明，溶液浓度、温度对微球粒径大小影响显著；压力对粒径分布影响显著．此研究为运用GAS法制备粒径较小，具有缓释、靶向、黏附等功能的乙基纤维素含药微球打下基础．
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| 关 键 词： | 超临界CO2 乙基纤维素 气体抗溶剂法 微球 |
Experimental study on the micronization of ethyl-cellulose by gas antisolvent process |
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| CHEN Lan,ZAHNG Yan,LI Bao-guo,WU Yi-wen,HUA Ze-zhao,LIU Zhe-peng,LU Wei-yue.Experimental study on the micronization of ethyl-cellulose by gas antisolvent process[J].Journal of University of Shanghai For Science and Technilogy(Social Science),2004,26(2):121-125. |
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| Authors: | CHEN Lan ZAHNG Yan LI Bao-guo WU Yi-wen HUA Ze-zhao LIU Zhe-peng LU Wei-yue |
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| Abstract: | The research covers the students who take this course in recent three years. It analyzes the characteristics of CAI for the course and compares the teaching effect of CAI with the previous ones when CAI was not adopted. The promotion of CAI in teaching is verified and the reason is given. It also mentions of some aspects to which special attention should be paid during the GAI designing and using. |
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| Keywords: | supercritical CO 2 ethyl-cellulose gas antisolvent microparticle |
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