On the Relationship Between Carcinogenicity and Acute Toxicity |
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Authors: | Bernhard Metzger Edmund Crouch Richard Wilson |
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Institution: | Energy and Environmental Policy Center, Jefferson Physical Laboratory, Harvard University, Cambridge, Massachussets 02138. |
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Abstract: | Parodi et al. (1) and Zeise et al. (2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. |
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Keywords: | Carcinogenicity acute toxicity correlation |
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