血清NTx和BSP对老年骨转移癌的临床意义

目的观察骨代谢生物标志物Ⅰ型胶原交联氨基末端肽（NTx）和骨唾液酸蛋白（BSP）在老年恶性肿瘤骨转移中的临床意义。方法老年恶性肿瘤患者96例，密切随访6个月以上，在入选时用ELISA法测定所有患者血清NTx和BSP基线水平，入选和随访6个月时应用影像学检查评估患者是否合并骨转移癌。结果骨转移癌组患者血清NTx和BSP基线水平均明显高于无骨转移组，NTx（25．70±12．67）nmol／L vs（11．20±4．74）nmol/L，P〈0．01；BSP（46．68±14．24）ng／mLvs（26．58±13．61）ng／mL，P〈0．01。骨痛程度与血清NTx和BSP基线水平正相关。随访中出现新发骨转移癌患者血清NTx和BSP基线水平显著高于无骨转移癌者，P〈0．01。结论血清NTx和BSP在老年恶性肿瘤骨转移的早期识别和预测中有重要的临床价值。

The clinical significance of serum NTx and BSP in the elderly with malignant bone metastasis

Objective To observe the correlation between bone markers,serum pyridinoline cross-linked N-telopeptides of type Ⅰ collagen （NTx） and serum bone sialoprotein （BSP）,and malignant bone metastases in old patients. Methods Old patients with malignant tumors were performed baseline serum NTx and BSP assessment by ELISA at enrollment （n=96）, then were classified as with or without bone metastases by radionuclide bone scans and bone radiographic surveys. Results There was a significant increase of baseline serum NTx and BSP in patients with bone metastases compared with those without bone metastases （P〈0.01）. Serum NTx and BSP have a positive relationship with the severity of metastatic bone pain. Elevated NTx and BSP at baseline was associated with new-onset bone metastases. Conclusions The new bone markers, NTx and BSP,can be used as early serum biological markers for recognition and prediction of malignant bone metastases in old patients.