剪切流场下超声微泡与内皮细胞黏附规律及其应用

新型超声造影剂(超声微泡)的开发已经逐渐成为超声医学的研究热点。该文综述了各类靶向超声微泡在外周血管疾病的超声诊断领域中的研究进展,尤其是在动脉粥样硬化早期诊断和分子影像中的应用。同时还深入阐述了靶向超声微泡在剪切流场下与血管内皮细胞之间的黏附动力学规律,为靶向超声微泡最终广泛应用于临床提供了实验依据和参考信息。

Adhesion of Targeted Microbubbles to Endothelial Cells and their Potential Applications in Diagnosis of Cardiovascular Diseases

Ultrasound and microbubbles have been widely used for diagnostic imaging in clinical fields without producing significant adverse effects for many decades.To further improve the image contrast,development of targeted microbubbles is becoming the hot subject of ultrasound medicine in recent years.The goal of this brief review is to illustrate selected examples of targeted microbubbles that have been applied to the arenas of atherosclerosis,thrombosis,and vascular biology.The adhesion interactions of targeted...