A permutation test approach to phase II historical control trials |
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| Authors: | Alan D Hutson Maurie Markman Mark F Brady |
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| Institution: | 1. University at Buffalo , New York , USA;2. University of Texas M.D. Anderson Cancer Center , Texas , USA |
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| Abstract: | In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology. |
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| Keywords: | clinical trial non-randomized |
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