| 汉族人群NTRK2基因多态性与精神分裂症关联研究 |
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| 引用本文： | 万行军,易正辉,方贻儒,洪武,吴志国,汪栋祥,张晨,胡莺燕,陈俊,苑成梅,禹顺英.汉族人群NTRK2基因多态性与精神分裂症关联研究[J].山东农业大学学报(社会科学版),2008(1). |
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| 作者姓名： | 万行军 易正辉 方贻儒 洪武 吴志国 汪栋祥 张晨 胡莺燕 陈俊 苑成梅 禹顺英 |
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| 作者单位： | 上海交通大学医学院附属精神卫生中心 200030 |
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| 基金项目： | 上海交通大学医学院2007-2008年度“博士创新基金”项目(BXJ0837);; 上海交通大学医学院附属精神卫生中心院级课题项目(05-12) |
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| 摘 要： | 目的在中国汉族人群中探讨神经营养性酪氨酸激酶2型受体(NTRK2)基因rs1187272多态性与精神分裂症的关联性。方法采用TAQMAN探针SNP基因分型技术在中国汉族人群中对100例精神分裂症患者及119例正常对照者进行NTRK2基因rs1187272的分型,并进行等位基因及基因型比较。结果患者组与正常对照组之间,NTRK2基因rs1187272多态的等位基因分布(χ2=1.78,df=1,P>0.05)和基因型分布(χ2=1.01,df=2,P>0.05)无明显差异;男、女患者与正常对照组之间,等位基因分布(χ2=2.70,df=3,P>0.05)和基因型分布(χ2=4.72,df=6,P>0.05)也无明显差异;但在不同发病年龄组之间,NTRK2基因rs1187272多态性等位基因分布(χ2=5.53,df=1,P=0.02)存在显著差异,在早发病患者组与对照组之间比较,NTRK2基因rs1187272多态性等位基因分布存在显著差异(χ2=4.38,df=1,P=0.04)。结论在中国汉族人群中NTRK2基因rs1187272多态性与早发精神分裂症(发病年龄≤25岁)存在关联,其可能是早发精神分裂症的易...
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| 关 键 词： | 早发精神分裂症 NTRK2基因 多态性 中国汉族人群 |
Association study between NTRK2 gene polymorphisms and schizophrenia in Chinese Han people |
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| Wan Xingjun; Yi Zhenghui; Fang Yiru; Hong Wu; Wu Zhiguo; Wang Dongxiang; Zhang Chen; Hu Yingyan; Chen Jun; Yuan Chengmei; Yu Shunying.Association study between NTRK2 gene polymorphisms and schizophrenia in Chinese Han people[J].Journal of Shandong Agricultural University,2008(1). |
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| Authors: | Wan Xingjun; Yi Zhenghui; Fang Yiru; Hong Wu; Wu Zhiguo; Wang Dongxiang; Zhang Chen; Hu Yingyan; Chen Jun; Yuan Chengmei; Yu Shunying |
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| Institution: | Wan Xingjun; Yi Zhenghui; Fang Yiru; Hong Wu; Wu Zhiguo; Wang Dongxiang; Zhang Chen; Hu Yingyan; Chen Jun; Yuan Chengmei; Yu Shunying.Shanghai Mental Health Center; Shanghai Jiaotong University; Shanghai 200030; |
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| Abstract: | Objective: To explore the relationships between Neurotrophic Tyrosine Kinase Receptor Type 2(NTRK2) gene polymorphisms and schizophrenia in Chinese Han population.Methods: The NTRK2 SNP rs1187272 were genotyped by applying TAQTaqMan(r) SNP Genotyping Assays in 100 patients with schizophrenia and 119 unrelated healthy controls,then the comparison of the alleles and genotypes frequencies of the NTRK2 gene between two groups was performed.Results:There was no significant difference in allele(χ2=1.78,df=1,P>... |
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| Keywords: | Schizophrenia with earlier first-onset age NTRK2 gene Polymorphisms Chinese Han population |
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