RNA multiple structural alignment with longest common subsequences

In this paper, we present a new model for RNA multiple sequence structural alignment based on the longest common subsequence. We consider both the off-line and on-line cases. For the off-line case, i.e., when the longest common subsequence is given as a linear graph with n vertices, we first present a polynomial O(n ²) time algorithm to compute its maximum nested loop. We then consider a slightly different problem—the Maximum Loop Chain problem and present an algorithm which runs in O(n ⁵) time. For the on-line case, i.e., given m RNA sequences of lengths n, compute the longest common subsequence of them such that this subsequence either induces a maximum nested loop or the maximum number of matches, we present efficient algorithms using dynamic programming when m is small. This research is partially supported by EPSCOR Visiting Scholar's Program and MSU Short-term Professional Development Program.