SIMEX estimation in case of correlated measurement errors

The simulation-extrapolation (SIMEX) approach of Cook and Stefanski (J. Am. Stat. Assoc. 89:1314–1328, 1994) has proved to be successful in obtaining reliable estimates if variables are measured with (additive) errors. In particular for nonlinear models, this approach has advantages compared to other procedures such as the instrumental variable approach if only variables measured with error are available. However, it has always been assumed that measurement errors for the dependent variable are not correlated with those related to the explanatory variables although such scenario is quite likely. In such a case the (standard) SIMEX suffers from misspecification even for the simple linear regression model. Our paper reports first results from a generalized SIMEX (GSIMEX) approach which takes account of this correlation. We also demonstrate in our simulation study that neglect of the correlation will lead to estimates which may be worse than those from the naive estimator which completely disregards measurement errors.