The role of sex steroid hormones in benign prostatic hyperplasia |
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| Authors: | Bernice Asiedu Yvonne Anang Adraina Nyarko Derek Amartey Doku Brodrick Y Amoah Sheila Santa |
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| Institution: | 1. Department of Medical Laboratory Sciences, University of Ghana School of Biomedical and Allied Health Sciences, Korle Bu, Accra, Ghana and;2. Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana |
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| Abstract: | Introduction: The etiology of benign prostatic hyperplasia (BPH) remains a mystery to scientists; estrogen/androgen imbalance in aged men has been implicated.Methods: Thirty (30) apparently healthy men and newly diagnosed BPH patients were recruited from the Ghana Police Hospital. Lower urinary tract syndrome (LUTS) and prostate volume were assessed via the prostate symptom score sheet (IPSS) and abdominopelvic scan, respectively. Laboratory assays for total prostate specific antigen (tPSA) and hormones androstenedione (AED), testosterone (T), dihydrotestosterone (DHT), androstanedioladiol (3α-adiol), androstanediol (3β-diol), estrone (E1) and estradiol (E2)] were performed via ELISA techniques. Non-parametric analyses were employed. p?Results: AED was significantly higher in controls compared to the BPH patients. AKRIC2 (3α-diol/DHT) was significantly higher in the BPH group (p?p=?0.029). Age correlated negatively with T, while a negative correlation was observed between TIPSS and 3β-diol and AKRIC1. Also, prostate volume correlated negatively with fT.tPSA correlated positively with E2 and aromatase activity (E2/T) and negatively with fT. On multiple linear regression, DHT and 3β-diol remained independent predictors for TIPSS and fT for tPSA.Conclusion: Estrogens and androstanediols seem to play a role in BPH development. |
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| Keywords: | Prostate androgens estrogen |
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