Androgen status in non-diabetic elderly men with heart failure |
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| Authors: | Goran Loncar Biljana Bozic Aleksandar N Neskovic Natasa Cvetinovic Mitja Lainscak Nenad Prodanovic |
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| Institution: | 1. Department of Cardiology, Zvezdara University Medical Center, Belgrade, Serbia;2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia;3. Institute for Medical Research, Military Medical Academy, Belgrade, Serbia;4. Institute for Physiology and Biochemistry, University of Belgrade, Belgrade, Serbia;5. Faculty of Medicine, University of Belgrade, Belgrade, Serbia;6. Department of Cardiology, University Hospital Zemun, Belgrade, Serbia;7. Departments of Cardiology, Research and Education, General Hospital Celje, Celje, Slovenia;8. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;9. Clinic for Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia |
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| Abstract: | Purpose: We aimed at evaluating androgen status (serum testosterone TT] and estimated free testosterone eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival.Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55?years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up.Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.79?±?1.65 vs. 4.45?±?1.68?ng/ml and 0.409?±?0.277 vs. 0.350?±?0.204?nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=?0.371, p?=?0.001) and adiponectin levels (r?=?0.349, p?=?0.002), while inverse association was noted with fat mass (r?=??0.413, p?<?0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p?<?0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up.Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome. |
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| Keywords: | Testosterone heart failure men adipokines survival body composition |
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