合并2型糖尿病的老年男性患者雄激素缺乏综合症与骨质疏松的关系

目的探讨合并2型糖尿病的老年男性患者雄激素缺乏综合症(PADAM)与骨质疏松的关系.方法老年男性雄激素缺乏综合症患者35例,伴2型糖尿病的PADAM患者36例,均采用放射免疫法测定游离睾酮(FT),定量CT测定骨密度(BMD),同时测定空腹和餐后2h血糖及糖化血红蛋白.结果伴有2型糖尿病的PADAM组FT水平和BMD低于PADAM组,后者又低于对照组(P＜0.001).结论老年男性雄激素缺乏综合症是骨质疏松发生的重要原因,若伴有糖尿病将加重骨质疏松的程度.

The relationship between partial androgen deficiency syndrome with type 2 diabetes mellitus and osteoporosis in the aging male

Objectives To discuss the association between partial androgen defi- ciency syndrome with type 2 diabetes mellitus and osteoporosis in the aging male. Methods Bone mineral density(BMD)was determined by quantitative CT and free testosteone(FT) were mensurated by radio immunoassay, at the same time fasting plasma gluoose(FBG) and a 2 hour postprandial plasma glucose(2hPBG)and HbA_(1c) were determined for 35 partial androgen deficiency syndrome(PADAM) and 36 partial androgen deficiency syndrome with type 2 diabetes mellitus in the aging male. Results The level of FT and BMD in partial androgen deficiency syndrome with type 2 dia- betes mellitus was lower than partial androgen deficiency syndrome without type 2 di- abetes, the later was lower than controls(P<0.001). Conclusions partial androgen deficiency syndrome in the aging male is one of important reason in osteoporosis, the degree of osteoporosis were encreased if there were type 2 diabetes mellitus.