| 复方曲安奈德乳膏的制备及质量研究 |
| |
| 引用本文： | 周秋云,张祖菲.复方曲安奈德乳膏的制备及质量研究[J].西南科技大学学报(哲学社会科学版),2009,7(4):14-15. |
| |
| 作者姓名： | 周秋云 张祖菲 |
| |
| 作者单位： | 江苏省南京市胸科医院,药剂科,210029 |
| |
| 摘 要： | 目的制备复方曲安奈德乳膏，建立其质量控制标准。方法以曲安奈德益和硝酸益康唑为主药制备成乳膏，用高效液相色谱法测定两种主药的含量，并制定其质量标准。结果曲安奈德益和硝酸益康唑含量分别在（8．105—40．525）μg／ml（r=0．9998，n=5）和（82．96-414．80）μg／ml（r=0．9996，n=5）范围内，与峰面积线性关系良好；平均回收率分别为100．1％和99．75％，RSD分别为0．13％（n=5）和0．69％（n=5）。结论复方曲安奈德乳膏性质稳定，质量控制方法简便，含量测定方法准确。
|
| 关 键 词： | 曲安奈德 乳膏剂 质量研究 |
Preparation and quality research of compound triamcinolone acetonide cream |
| |
| ZHOU Qiuyun,ZHANG Zufei,Medicament section of Nanjing Chest Hospital,Nanjing ,China..Preparation and quality research of compound triamcinolone acetonide cream[J].Journal of Southwest University of Science and Technology,2009,7(4):14-15. |
| |
| Authors: | ZHOU Qiuyun ZHANG Zufei Medicament section of Nanjing Chest Hospital Nanjing China |
| |
| Institution: | ZHOU Qiuyun,ZHANG Zufei,Medicament section of Nanjing Chest Hospital,Nanjing 210029,China. |
| |
| Abstract: | Objective To investigate the preparation compound triamcinolone acetonide cream and establish the quality standard of it. Methods Triamcinolone acetonide and econazole nitrate were determined by HPLC. Results The calibration curves were linear in the range of （8.105-40.525）μg/ml for triamcinolone acetonide and （82.96-414.80）μg/ml for econazole nitrate,respectively. The recoveries of triamcinolone acetonide and econazole nitrate were 100.1% and 99.75% ,respectively. Conclusion The cream showed a good stability.The method is simple and convenient in operation. |
| |
| Keywords: | Triamcinolone acetonide Cream Quality research |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
