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Benzene Risk Estimation Using Radiation Equivalent Coefficients
Authors:Aki Nakayama  Tomomi Isono  Takuro Kikuchi  Iichiro Ohnishi  Junichiro Igarashi  Minoru Yoneda  Shinsuke Morisawa
Institution:1. Kyoto University, Graduate School of Engineering, Urban and Environmental Engineering, Kyoto Daigaku Katsura 4, Nishikyo, Kyoto, 615-8540, Japan.;2. Research & Development Institute, Takenaka Corporation, 1-5-1, Otsuka, Inzai-shi, Chiba, 270-1395, Japan.
Abstract:We estimated benzene risk using a novel framework of risk assessment that employed the measurement of radiation dose equivalents to benzene metabolites and a PBPK model. The highest risks for 1 μg/m3 and 3.2 mg/m3 life time exposure of benzene estimated with a linear regression were 5.4 × 10?7 and 1.3 × 10?3, respectively. Even though these estimates were based on in vitro chromosome aberration test data, they were about one-sixth to one-fourteenth that from other studies and represent a fairly good estimate by using radiation equivalent coefficient as an "internal standard."
Keywords:Benzene  chromosome aberration  PBPK model  radiation equivalent coefficient  tissue dose
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