ON A SHARED ALLELE TEST OF RANDOM MATING

A simple random sample is observed from a population with a large number‘K’ of alleles, to test for random mating. Of n couples, n_ijkl have female genotype ij and male genotype kl (i, j, k, l{1,…, A‘}). The large contingency table is collapsed into three counts, n₀, n₁ and n₂ where n_p is the number of couples with s alleles in common (s = 0,1, 2). The counts are estimated by np?_o where n₀, is the estimated probability of a couple having s alleles in common under the hypothesis of random mating. The usual chi-square goodness of fit statistic X² compares observed (n_s) with expected (np?) over the three categories, s = 0,1,2. An empirical observation has suggested that X² is close to having a chi-square distribution with two degrees of freedom (X) despite a large number of parameters implicitly estimated in _e. This paper gives two theorems which show that x is indeed the approximate distribution of X² for large n and K₁“, provided that no allele type over-dominates the others.