Minimal circular strongly balanced repeated measurements designs in periods of three different sizes

Repeated measurements designs (RMD) are widely used in medicine, pharmacology, animal sciences, and psychology. If there is a restriction on the total number of treatments, some experimental units can receive on the total length of time while some experimental units can remain in the trial, then RMD in periods of unequal sizes should be used. In this article, some infinite series are developed to generate the minimal circular strongly balanced RMD in periods of three different sizes p₁, p₂, and p₃, where 2 ≤ p₃ < p₂ ≤ 10.     

Minimal circular balanced repeated measurement designs in unequal period sizes

Abstract

Repeated measurement designs (RMDs) are widely used in medicine, pharmacology, animal sciences and psychology. In these fields, there are several situations where these designs should be used in periods of different sizes. With the use of RMD, residual effects or carry over effects may arise and balanced RMDs are solution to this problem. In this article, therefore, some infinite series are developed through method of cyclic shifts to obtain circular balanced repeated measurements designs in periods of two different sizes.     

Construction of circular partially balanced-Repeated measurement designs using cyclic shifts

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences and psychology. These designs balance out the residual effects. The situations where balanced repeated measurements designs require a large number of the subjects, partially-balanced repeated measurements designs should be used. In this paper some infinite series are developed which provide circular partially-balanced repeated measurement designs for p (periods) even. Catalogues of circular partially-balanced repeated measurement designs are also presented for v (treatments) ≤ 100 with p = 5, 7 & 9.     

Some new construction of circular weakly balanced repeated measurements designs in periods of two different sizes

Abstract

Balanced repeated measurements designs (RMDs) balance out the residual effects. Williams Latin square designs work as minimal combinatorial balanced as well as variance balanced for RMDs for p (period sizes) = v (number of treatments). If minimal balanced RMDs cannot be constructed for the situations where p must be less than v then weakly balanced RMDs should be preferred. In this article, some generators are developed to generate circular weakly balanced RMDs in periods of two different sizes. To obtain the proposed designs, some construction procedures are also described for some of the cases where we could not develop generators.     

Some new constructions of circular balanced repeated measurements designs

Repeated measurements designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this article, some infinite series are developed to generate the balanced repeated measurements designs for p (periods) even. For p odd, construction procedures are also described. Catalogues of the proposed designs are also presented for p = 5, 7, 9, when v ≤ 100.     

Construction of repeated measurements designs strongly balanced for residual effects

Abstract

Repeated Measurements Designs have been widely used in agriculture, animal husbandry, education, biology, botany and engineering. Balanced or strongly balanced repeated measurements designs are useful to balance out the residual effects. In this article, some new generators and construction procedures are proposed to obtain circular strongly balanced repeated measurements designs in periods of (a) equal sizes, (b) two different sizes, and (c) three different sizes.     

Some extensions of circular balanced and circular strongly balanced repeated measurements designs

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this paper the works of Iqbal and Tahir (2009 Iqbal, I., and M. H. Tahir. 2009. Circular strongly balanced repeated measurements designs. Communications in Statistics—Theory and Methods 38:3686–96.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and Iqbal, Tahir, and Ghazali (2010 Iqbal, I., M. H. Tahir, and S. S. A. Ghazali. 2010. Circular first- and second-order balanced repeated measurements designs. Communications in Statistics—Theory and Methods 39:228–40.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) are generalized for the construction of circular-balanced and circular strongly balanced repeated measurements designs through the method of cyclic shifts for three periods.     

Circular First- and Second-Order Balanced Repeated Measurements Designs

Sharma (1977 Sharma , V. K. ( 1977 ). Change-over designs with complete balance for first and second order residual effect . Canad. J. Statist. 5 : 121 – 132 .[Crossref] , [Google Scholar]) and Aggarwal et al. (2006 Aggarwal , M. L. , Deng , L.-Y. , Jha , M. K. ( 2006 ). Balanced residual treatment effects designs of first and second order . Statist. Probab. Lett. 76 : 597 – 600 .[Crossref], [Web of Science ®] , [Google Scholar]) considered non circular construction of first- and second-order balanced repeated measurements designs. Sharma et al. (2002 Sharma , V. K. , Varghese , C. , Jaggi , S. ( 2002 ). On optimality of change-over designs balanced for first and second order residual effects . Metron 60 : 153 – 162 . [Google Scholar]) constructed circular first- and second-order balanced repeated measurements designs only for a class with parameters (v, p = 3n, n = v ²) and also showed its universal optimality. In this article, we consider circular construction of first- and second-order balanced repeated measurements designs and strongly balanced repeated measurements designs by using the method of cyclic shifts. Some new circular designs with parameters (v, p, n) for cases p = v, p < v and p > v are given.     

TABLES OF SMALL OPTIMAL REPEATED MEASUREMENTS DESIGNS

This paper presents tables of the optimal repeated measurements designs for the estimation of direct effects and of residual effects for a model with independent errors, for up to n = 10 experimental units, for t= 2 treatments and p= 2, 3 or 4 periods, and for t= 3 treatments and p= 2 or 3 periods.     

Efficient crossover designs in the presence of interactions between direct and carry-over treatment effects

Crossover designs, or repeated measurements designs, are used for experiments in which t treatments are applied to each of n experimental units successively over p time periods. Such experiments are widely used in areas such as clinical trials, experimental psychology and agricultural field trials. In addition to the direct effect on the response of the treatment in the period of application, there is also the possible presence of a residual, or carry-over, effect of a treatment from one or more previous periods. We use a model in which the residual effect from a treatment depends upon the treatment applied in the succeeding period; that is, a model which includes interactions between the treatment direct and residual effects. We assume that residual effects do not persist further than one succeeding period.A particular class of strongly balanced repeated measurements designs with n=t² units and which are uniform on the periods is examined. A lower bound for the A-efficiency of the designs for estimating the direct effects is derived and it is shown that such designs are highly efficient for any number of periods p=2,…,2t.     

Circular Strongly Balanced Repeated Measurements Designs

Magda (1980 Magda , C. G. ( 1980 ). Circular balanced repeated measurements designs . Commun. Statist. Theor. Meth. 9 : 1901 – 1918 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and Hedayat (1981 Hedayat , A. S. ( 1981 ). Repeated measurements designs-IV: recent advances (with discussion) . Bull. Int. Statist. Inst. 1 : 591 – 610 . [Google Scholar]) first considered the construction of circular strongly balanced repeated measurements designs. Sen and Mukerjee (1987 Sen , M. , Mukerjee , R. ( 1987 ). Optimal repeated measurements designs under interaction . J. Statist. Plann. Infer. 17 : 81 – 91 .[Crossref], [Web of Science ®] , [Google Scholar]) and Roy (1988 Roy , B. K. ( 1988 ). Construction of strongly balanced uniform repeated measurements designs . J. Statist. Plann. Infer. 19 : 341 – 348 .[Crossref], [Web of Science ®] , [Google Scholar]) considered the optimality and existence of circular strongly balanced repeated measurements designs based on the method of differences and Hamiltonian decomposition of lexicographic product of two graphs. In this article, we consider the construction of circular strongly balanced repeated measurements designs using the newly proposed method called cyclic shifts, and propose some new designs for p < v.     

Generalized Bhaskar Rao designs

Generalized Bhaskar Rao designs with non-zero elements from an abelian group G are constructed. In particular this paper shows that the necessary conditions are sufficient for the existence of generalized Bhaskar Rao designs with k=3 for the following groups: ?G? is odd, G=Z^r₂, and G=Z^r₂×H where 3? ?H? and r?1. It also constructs generalized Bhaskar Rao designs with υ=k, which is equivalent to υ rows of a generalized Hadamard matrix of order n where υ?n.     

Construction of minimum aberration blocked two-level regular factorial designs

ABSTRACT

In this article, we consider the construction of minimum aberration 2^{n ? k}: 2^p designs with respect to some existing combined wordlength patterns, where a 2^{n ? k}: 2^p design is a blocked two-level design with n treatment factors, 2^p blocks, and N = 2^q runs with q = n ? k. Two methods are proposed for two situations: n ? 2^{q ? p} ? 1 and n > N/2. These methods enable us to obtain some new minimum aberration 2^{n ? k}: 2^p designs from existing minimum aberration unblocked and blocked designs. Examples are included to illustrate the theory.     

Optimal repeated measurements designs for comparing test treatments with a control

A-optimal and mv optimal repeated measurments designs for comparing serveral test treatments with a control are considered. the models considered are basically of two types: without preperides and the cirular model. It is shown known that some known strongly balanced uniform repeated measurements designs can be modified to obtain optimal designs for this problem. Some other methods of finding optimal designs are also given.     

Construction of Neighbor-Balanced Designs in Linear Blocks

Neighbor-balanced designs are useful to remove the neighbor effects in experiments where the performance of a treatment is affected by the treatments applied to its adjacent neighbors. In this article, neighbor-balanced designs are constructed in linear blocks of (i) equal sizes and (ii) two different sizes k ₁ and k ₂.     

Non binary partially neighbor balanced designs for circular blocks

ABSTRACT

Neighbor designs are recommended for the cases where the performance of treatment is affected by the neighboring treatments as in biometrics and agriculture. In this paper we have constructed two new series of non binary partially neighbor balanced designs for v = 2n and v = 2n+1 number of treatments, respectively. The blocks in the design are non binary and circular but no treatment is ever a neighbor to itself. The designs proposed here are partially balanced in terms of nearest neighbors. No such series are known in the literature.     

A note on circular neighbor balanced designs

ABSTRACT

This paper describes some methods of constructing circular neighbor balanced and circular partially neighbor balanced block designs for estimation of direct and neighbor effects of the treatments. A class of circular neighbor balanced block designs with unequal block sizes is also proposed.     

Repeated measurements designs with unequal period sizes

Summary This paper is concerned with the designs in which each experimental unit is assigned more than once to a treatment, either different or identical. An easy method of constructing balanced minimal repeated measurements designs with unequal period sizes is presented whenever the number of periods is less than the number of treatments. Strongly balanced minimal repeated measurements designs with unequal period sizes are also constructed whenever the number of periods is less than the number of treatments.     

Some series of proper generalized neighbor designs

Neighbor balanced designs are used to remove the neighbor effects but most of these designs require a large number of blocks. To neutralize the neighbor effects in such situations, GN₂-designs are most desirable. This article deals with the (i) refinement of some series of GN₂-designs constructed by Zafaryab et al. (2010) and (ii) construction of some new series of GN₂-designs in circular blocks of equal size.