Some new constructions of circular balanced repeated measurements designs

Repeated measurements designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this article, some infinite series are developed to generate the balanced repeated measurements designs for p (periods) even. For p odd, construction procedures are also described. Catalogues of the proposed designs are also presented for p = 5, 7, 9, when v ≤ 100.     

Some new construction of circular weakly balanced repeated measurements designs in periods of two different sizes

Abstract

Balanced repeated measurements designs (RMDs) balance out the residual effects. Williams Latin square designs work as minimal combinatorial balanced as well as variance balanced for RMDs for p (period sizes) = v (number of treatments). If minimal balanced RMDs cannot be constructed for the situations where p must be less than v then weakly balanced RMDs should be preferred. In this article, some generators are developed to generate circular weakly balanced RMDs in periods of two different sizes. To obtain the proposed designs, some construction procedures are also described for some of the cases where we could not develop generators.     

Construction of repeated measurements designs strongly balanced for residual effects

Abstract

Repeated Measurements Designs have been widely used in agriculture, animal husbandry, education, biology, botany and engineering. Balanced or strongly balanced repeated measurements designs are useful to balance out the residual effects. In this article, some new generators and construction procedures are proposed to obtain circular strongly balanced repeated measurements designs in periods of (a) equal sizes, (b) two different sizes, and (c) three different sizes.     

Designs with Repeated Measurements on Any Number of Units over Varying Periods

In the usual repeated measurements designs (RMDs), the subjects are all observed for the same number of periods and the optimum RMDs require specified numbers of subjects, usually depending on the number of treatments to be used. In practice, it is sometimes not feasible to meet these requirements. To overcome this problem, alternative designs are suggested where any number of available subjects may be used and they may be observed for different periods. These designs are based on suitable serially balanced sequences which are shown to be optimal. Moreover, besides the usual direct and residual effects, the model considered has an extra term due to the interaction effect between them. The recommended designs are universally optimal in a very general class.     

Some extensions of circular balanced and circular strongly balanced repeated measurements designs

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this paper the works of Iqbal and Tahir (2009 Iqbal, I., and M. H. Tahir. 2009. Circular strongly balanced repeated measurements designs. Communications in Statistics—Theory and Methods 38:3686–96.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and Iqbal, Tahir, and Ghazali (2010 Iqbal, I., M. H. Tahir, and S. S. A. Ghazali. 2010. Circular first- and second-order balanced repeated measurements designs. Communications in Statistics—Theory and Methods 39:228–40.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) are generalized for the construction of circular-balanced and circular strongly balanced repeated measurements designs through the method of cyclic shifts for three periods.     

Designs balanced for circular residual effects

Magda (1980) introduced a model for repeated measurements designs with a circular structure of the residual effects. He proved the universal optimality of circular balanced uniform designs over a subclass of the possible designs. We strengthen his result to optimality over the set of all designs with the same number of experimental units, periods and treatments.     

Construction of circular partially balanced-Repeated measurement designs using cyclic shifts

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences and psychology. These designs balance out the residual effects. The situations where balanced repeated measurements designs require a large number of the subjects, partially-balanced repeated measurements designs should be used. In this paper some infinite series are developed which provide circular partially-balanced repeated measurement designs for p (periods) even. Catalogues of circular partially-balanced repeated measurement designs are also presented for v (treatments) ≤ 100 with p = 5, 7 & 9.     

Minimal circular strongly balanced repeated measurements designs in periods of three different sizes

Repeated measurements designs (RMD) are widely used in medicine, pharmacology, animal sciences, and psychology. If there is a restriction on the total number of treatments, some experimental units can receive on the total length of time while some experimental units can remain in the trial, then RMD in periods of unequal sizes should be used. In this article, some infinite series are developed to generate the minimal circular strongly balanced RMD in periods of three different sizes p₁, p₂, and p₃, where 2 ≤ p₃ < p₂ ≤ 10.     

Circular balanced repeated measurements designs

The concept of a circular design is defined and when proper balance for various effects is assumed, its universal optimality is proved over the class of all designs with the same set of parameters, Such designs are shown to minimize the variance of the best linear unbiased estimators of contrasts of residual and direct effects over the class of equireplicated designs. All models assume first order residual effects and are of a circular nature. The proofs are presented in a unified manner for several models at a time. They are based on certain matrix domination which occurs when parameters are eliminated from a linear modelj this latter fact is proved for a general linear model.     

Repeated measurements designs - a review

Any experiment in which one or more of the experimental units is used more than once is called a repeated measurements experiment. The associated design of a repeated measurements experiment is referred to as a repeated measurements design. This review covers some known results on repeated measurements designs. Emphasis is placed on the impact of optimal design theory. Some construction methods for these designs are presented. Hedayat and Afsarinejad (1975) has an extensive bibliography of earlier literature. A bibliography of these designs published after 1974 is provided at the end of this paper.     

Minimal circular balanced repeated measurement designs in unequal period sizes

Abstract

Repeated measurement designs (RMDs) are widely used in medicine, pharmacology, animal sciences and psychology. In these fields, there are several situations where these designs should be used in periods of different sizes. With the use of RMD, residual effects or carry over effects may arise and balanced RMDs are solution to this problem. In this article, therefore, some infinite series are developed through method of cyclic shifts to obtain circular balanced repeated measurements designs in periods of two different sizes.     

Circular balanced repeated measurement designs in periods of three different sizes

Abstract

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences and psychology. If there is a restriction on the total number of treatments, some experimental units can receive on the total length of time while some experimental units can remain in the trial, then repeated measurements designs with unequal period sizes should be used. In this article, some infinite series are developed to generate the minimal balanced repeated measurement designs in periods of three different sizes p₁, p₂ and p₃, where 2?≤?p₃?<?p₂ ≤ 10 and p₂?<?p₁.     

Repeated measurements designs with unequal period sizes

Summary This paper is concerned with the designs in which each experimental unit is assigned more than once to a treatment, either different or identical. An easy method of constructing balanced minimal repeated measurements designs with unequal period sizes is presented whenever the number of periods is less than the number of treatments. Strongly balanced minimal repeated measurements designs with unequal period sizes are also constructed whenever the number of periods is less than the number of treatments.     

TABLES OF SMALL OPTIMAL REPEATED MEASUREMENTS DESIGNS

This paper presents tables of the optimal repeated measurements designs for the estimation of direct effects and of residual effects for a model with independent errors, for up to n = 10 experimental units, for t= 2 treatments and p= 2, 3 or 4 periods, and for t= 3 treatments and p= 2 or 3 periods.     

Optimal and efficient crossover designs for comparing test treatments to a control treatment under various models

We study the optimality, efficiency, and robustness of crossover designs for comparing several test treatments to a control treatment. Since A-optimality is a natural criterion in this context, we establish lower bounds for the trace of the inverse of the information matrix for the test treatments versus control comparisons under various models. These bounds are then used to obtain lower bounds for efficiencies of a design under these models. Two algorithms, both guided by these efficiencies and results from optimal design theory, are proposed for obtaining efficient designs under the various models.     

Approximate theory of multiway block designs

Optimality properties of multiway block designs are deduced from the general results of J. Kiefer's approximate-design theory. In the model with additive effects these optimality properties solely depend on the two-dimensional marginals of the designs. Uniform designs, and designs whose two-dimensional marginals are products of the one-dimensional marginals, are shown to be optimal. Approximate Youden designs are introduced for the case when the support sets of the two-dimensional marginals are prescribed in advance. They are optimal in a relatively small class of competing designs only.     

D-minimax Second-order Designs Over Hypercubes for Extrapolation and Restricted Interpolation Regions

The D-minimax criterion for estimating slopes of a response surface involving k factors is considered for situations where the experimental region χ and the region of interest ? are co-centered cubes but not necessarily identical. Taking χ = [ ? 1, 1]^k and ? = [ ? R, R]^k, optimal designs under the criterion for the full second-order model are derived for various values of R and their relative performances investigated. The asymptotically optimal design as R → ∞ is also derived and investigated. In addition, the optimal designs within the class of product designs are obtained. In the asymptotic case it is found that the optimal product design is given by a solution of a cubic equation that reduces to a quadratic equation for k = 3?and?6. Relative performances of various designs obtained are examined. In particular, the optimal asymptotic product design and the traditional D-optimal design are compared and it is found that the former performs very well.     

A study of BIB designs through support matrices

This paper deals with the existence and nonexistence of BIB designs with repeated blocks. The approach is an algebraic one. The concept of a support matrix is introduced and some of its basic properties are noted. Some basic examples of support matrices are given when the block size is 3. The connection between full column rank proper support matrices and irreducible designs is explored and some examples of such matrices are given.     

Bayes a-opttmal and efficient block designs for comparing test treatments with a standard treatment

A sufficient condition for the Bayes A-optimality of block designs when comparing a standard treatment with v test treatments is given by Majumdar. (In:Optimal Design and Analysis of Experiments, Y. Dodge, V. V. Fedorov and H. P. Wynn (Eds.), 15-27, North-Holland, 1988). The priors that he considers depend on a constant α ε [0, ∞), with α - 0 corresponding to no prior information at all. The given sufficient condition, consequently, also depends on a. Large families of optimal and highly efficient designs are only known for the case α - 0. We will show how some of the results for α - 0 can be extended to obtain large families of optimal and highly efficient designs for arbitrary values of α. In addition, these results are useful when considering design robustness against an improper choice of α.