一类带有分布参数系统的最佳控制

本文给出一类非均匀弦的横向振动的最佳控制，推广了P C Park的结果。这一结果同样适用于同类型振动问题。     

人的视觉心理艺术浅析

本文就人的视觉在对事物的色彩、形式、形状、光和影等诸方面,所产生的心理艺术影响作了剖析。并论述了视觉心理在电影、绘画等艺术创作中的重要性。从而激励人们更好地关注和创作美的作品。     

实用电源变压器检测台

该电路设计简单、构思新颖 ,适合小批量测试小型电源变压器的空载电流、额定电流及次级空载电压、满载电压、负载电流等参数     

数值解法中的单元形状函数技巧

本文介绍从一组互不相关的函数中推导数值法中单元形状函数的简便而有效的算法,以特定的一维内插方法导出各种二维、三维的内插方法,它们对奇异性的模拟是有益的;为了适用于延伸到无限远的单元,假设形状函数类似于Lagrange多项式,但包含了一个按指数衰减的项。     

Estimation of noncentrality parameters

We propose some estimators of noncentrality parameters which improve upon usual unbiased estimators under quadratic loss. The distributions we consider are the noncentral chi-square and the noncentral F. However, we give more general results for the family of elliptically contoured distributions and propose a robust dominating estimator.     

西部民族地区社会现代化与现代人格的塑造

为适应西部民族地区社会现代化的发展,必须要塑造与之相应的现代人格。文章对现代人格的特征以及西部民族地区塑造现代人格的现实可行性进行了阐述,并提出了塑造现代人格的基本对策。     

Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

涡轮叶片尾缘针肋的换热研究

以涡轮叶片尾缘中针肋通道的换热为研究对象，讨论并计算出了一定条件下获得最大针肋通道换热量时针肋的形状曲线和换热优势，系统分析了这种拥有最佳形状曲线针肋的通道散热量随针肋物性参数及几何特征变化的规律。     

湖南省省属高校经常性财政拨款新模式构建研究

经过近几年来高校管理体制的大幅度调整变化,目前湖南省省属高校所采用的经常性财政拨款方案已不能适应新形式的需要。成为适时之需,构建一种公平合理、简单有效的新模式,既发挥财政拨款在高教事业中的基础作用,又引导高校不断提高办学效益。     

Physiologically Based Liver Modeling and Risk Assessment

Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments.