Modifications of sequential designs in bioequivalence trials

Bioequivalence (BE) studies are designed to show that two formulations of one drug are equivalent and they play an important role in drug development. When in a design stage, it is possible that there is a high degree of uncertainty on variability of the formulations and the actual performance of the test versus reference formulation. Therefore, an interim look may be desirable to stop the study if there is no chance of claiming BE at the end (futility), or claim BE if evidence is sufficient (efficacy), or adjust the sample size. Sequential design approaches specially for BE studies have been proposed previously in publications. We applied modification to the existing methods focusing on simplified multiplicity adjustment and futility stopping. We name our method modified sequential design for BE studies (MSDBE). Simulation results demonstrate comparable performance between MSDBE and the original published methods while MSDBE offers more transparency and better applicability. The R package MSDBE is available at https://sites.google.com/site/modsdbe/ . Copyright © 2015 John Wiley & Sons, Ltd.     

Talking Prose All These Years: Agent‐Based Modeling as Process‐Oriented Analysis

This article considers the implications of an approach to computer simulation called agent‐based modeling for process‐oriented analysis. It argues that many theoretical and methodological debates found in the latter field can be effectively advanced by the former. The argument is presented and then extended using a ubiquitous agent‐based model proposed to improve understanding of ethnic residential segregation. The argument has three strands. The first is that theoretical and methodological debates are unlikely to progress unless they can be “cashed out” empirically. The second is that agent‐based modeling (and its distinctive methodology) has capabilities to do this that existing research methods lack and, in fact, that agent‐based models are a natural way to represent “social process” as apparently conceived by process‐oriented analysis. The third is that possibilities exist for productive synthesis between agent‐based modeling and process‐oriented analysis with the former clarifying, instantiating, and perhaps even testing notions of process developed by the latter.     

涉警舆情的成因探析

目前,涉警舆情引起社会公众的高度关注,搞清楚涉警舆情的来龙去脉,才能使得涉警舆情呈现出正能量。从成因入手,对涉警舆情形成的各个要素进行客观分析。涉警舆情的成因也可分为社会、主体和客体三个方面:社会成因主要包括群众的利益诉求、社会矛盾的冲突、法制建设的缺失;主体方面的成因则为民众自身素质、个体极端事件诱发和敌对势力煽动;客体方面的成因主要是警察伦理建设的缺失。     

Cyclical Evolution of the Global Right

An understanding of the current right‐wing national and transnational social movements can benefit from comparing them to the global and national conditions operating during their last appearance in the first half of the twentieth century and by carefully comparing twentieth‐century fascism with the neofascist and right‐wing populist movements that have been emerging in the twenty‐first century. This allows us to assess the similarities and differences, and to gain insights about what could be the consequences of the reemergence of populist nationalism and fascist movements. Our study uses the comparative evolutionary world‐systems perspective to study the Global Right from 1800 to the present. We see fascism as a form of capitalism that emerges when the capitalist project is in crisis. World historical waves of right‐wing populism and fascism are caused by the cycles of globalization and deglobalization, the rise and fall of hegemonic core powers, long business cycles (the Kondratieff wave), and interactions with both Centrist Liberalism and the Global Left. We consider how crises of the global capitalist system have produced right‐wing backlashes in the past, and how a future terminal crisis of capitalism could lead to a reemergence of a new form of authoritarian global governance or a reorganized global democracy in the future.     

广西沿边"适应-竞争-合作"式 城镇演化模式研究 ——以凭祥、东兴为例

新时代不充分不平衡发展问题突出，加大力度支持边疆民族地区加快发展的要求迫在眉睫。广西沿边民族地区发展总体滞后，城镇发展模式趋同；东兴和凭祥在沿边城镇发展模式趋同的情况下，在“适应-竞争-合作”式城镇演化过程中，充分利用国家政策、发挥比较优势、培育优势特色产业、深化内外合作，实现了城镇经济的跨越式发展。本文以生物学“趋同进化”理论为基础，结合新发展理念和东兴、凭祥的发展经验建议：广西沿边民族地区采取“适应-竞争-合作”式城镇发展模式，以创新增强各城镇内生动力，以互补合作促进协调发展，以绿色发展道路助推城镇发展的可持续性，以加强内外市场的联动性来深化城镇开放、合作式发展，以“省-市-县”、“县-镇-村”的互联互通推进共享发展。     

冷战后的中美政治安全关系

冷战结束十年以来 ,美国的对华政策依然摇摆不定。之所以如此 ,是因为十年来美国视中国为敌还是为友 ,或者非敌非友 ,至今还未定性。而美国难于在其国际政治安全战略中给中国定性的原因 ,则与以下的三个层次密切相关 ,即美国的国内政治层次、中美关系的发展层次和全球层次。     

金诗学唐的历程

金代诗歌在受苏轼等宋代诗人的影响之外 ,也受到唐诗的浸润。本文依据金诗发展变化的自身情况 ,考察了金诗学唐的历程。文中将金诗学唐分为金初“借才异代”时期、“国朝文派”时期、金代后期等三个阶段 ,做了比较详细的论述 ,从一个方面展示了金诗发展的轨迹 ,揭示了金诗的某些重要特点 ,对于我们深入地认识金诗是有裨益的     

关于体育教育专业学生能力培养的研究

通过查阅文献资料和问卷调查反馈,研究分析发现,当前体育教育专业学生能力还不能适应社会发展的需要,且发展不平衡。我们认为,对体育教育专业学生能力的培养应从师德教育、教学表达能力、教学组织能力、教学设计能力、适应教学环境的能力、体育教学自修与改革能力、社会竞争能力等方面下手,使学生的能力在四学年的教学实践活动中,得到有序全面的锻炼和提高、达到最佳培养效果。为他们将来成为合格的、高素质的复合型人才打下坚实的基础。     

土地利用规划约束机制研究

一、问题的提出 在一切能为人类所利用的自然资源中,土地是最基本且最宝贵的资源,是世代相传的人类不能出让的生存条件和再生产条件.