Reducing sample size needed for cox-proportional hazards model analysis using more efficient sampling method

Abstract

In general, survival data are time-to-event data, such as time to death, time to appearance of a tumor, or time to recurrence of a disease. Models for survival data have frequently been based on the proportional hazards model, proposed by Cox. The Cox model has intensive application in the field of social, medical, behavioral and public health sciences. In this paper we propose a more efficient sampling method of recruiting subjects for survival analysis. We propose using a Moving Extreme Ranked Set Sampling (MERSS) scheme with ranking based on an easy-to-evaluate baseline auxiliary variable known to be associated with survival time. This paper demonstrates that this approach provides a more powerful testing procedure as well as a more efficient estimate of hazard ratio than that based on simple random sampling (SRS). Theoretical derivation and simulation studies are provided. The Iowa 65+ Rural study data are used to illustrate the methods developed in this paper.     

政府减排目标、产业结构与污染减排

政府是污染减排的重要主体,了解其行为对污染减排的作用对提升污染减排效果及实现中国绿色发展具有重要意义。创造性地将政府减排目标纳入研究框架,构建面板门槛模型,从工业污染排放总量的角度分析政府减排目标、产业结构、经济规模等因素对地方污染减排的影响,并用工业污染物强度进行稳健性检验。结果显示,政府减排目标对污染减排的作用存在阶段性不同:经济发展初级阶段,政府减排目标对污染排放总量的作用方向为正; 经济发展水平较高时,作用方向为负; 两者之间存在适应性调整阶段,作用方向具有不确定性,但总体由正向作用向负向作用转变。产业结构对工业污染排放总量的作用方向因污染物种类而异,经济规模对工业污染排放总量作用方向为正。     

‘Public toilets for a diverse neighborhood’: Spatial purification practices in community development discourse

This paper explores the dialectic of place and community identity in Mount Pleasant, a multi–ethnic and multi–class U.S. neighborhood where definitions of place are hotly contested among its residents. In a grant proposal for public toilets, Mount Pleasant writers use linguistic strategies such as presupposition, deixis, and contrast, coupled with discursive themes of filth and geography, to construct a core of the Mount Pleasant community. The writers place themselves and people who share their values in that core, and immigrants at the margins. These strategies serve as a discursive type of spatial purification practice (cf. Sibley 1988) through which the grantwriters set up a moral and spatial order where they and other core community members are deemed to use space ‘appropriately’, and thus inhabit positive moral positions, while immigrant community members’ imputed ‘inappropriate’ use of space is used to construct negative moral positions for them.     

如何当好项目经理

项目经理是项目管理的核心 ,项目经理的素质、知识和管理水平 ,是工程建设项目的实施管理的关键 ,责权利的协调一致则是项目经理负责制的根本保证     

试析我国房地产投资运作模式及其发展

随着我国房地产市场由卖方市场逐渐过渡到买方市场,房地产投资运作模式由作坊生产式投资模式逐渐向社会化大生产式投资模式椎进。     

客户生命周期模式研究

客户关系具有周期性,可划分为考察期、形成期、稳定期和退化期四个阶段.交易额和客户利润被选作特征变量来描述客户关系水平,理论分析表明:两者均随生命周期阶段的发展而不断提升,考察期最小,形成期次小,稳定期最大.实证研究检验了该结论的正确性.根据客户关系退出时所处的阶段,客户生命周期模式被分成早期流产型、中途夭折型、提前退出型、长久保持型四种基本类型,每种类型均有不同的成因.     

促性腺激素、V_(D_3)、V_E亚硒酸钠对母兔繁殖力的影响

选择成年、健康、未孕母兔 32只 ,随机分成 8组 ,分别给予促性腺激素 (Ⅰ组 )、VD3(Ⅱ组 )、VE 亚硒酸钠 (Ⅲ组 ) ,促性腺激素 +VD3(Ⅳ组 )、VD3+VE 亚硒酸钠 (Ⅴ组 )、促性腺激素 +VE 亚硒酸钠(Ⅵ组 )、促性腺激 +VD3+VE 亚硒酸钠 (Ⅶ组 ) ,空白对照 8种处理。试验结果表明 ,母兔经药物处理后 ,其繁殖性能 (发情状况、排卵数、正常受精卵数 )都比对照组显著地提高 ,但Ⅰ、Ⅳ、Ⅵ组有畸形卵子存在 ,以处理Ⅶ组效果最好 ,其排卵数达 4 7± 2 0 .3个 ,正常受精卵 35个 ,分别比对照组多 36 .5个、30个。     

理论确证的类比模型解释

理论确证是科学哲学主要讨论的一个问题,但是在传统的归纳和演绎解释框架中,这一问题并未得到 彻底解决,它的两种解决策略都有难以克服的“确证悖论”。而从新的角度给予理论确证以比较完善的解释是一种 策略,类比模型为这一策略的实现提供了现实可行的方案。     

农业高科技企业成长机会价值量化模型构建及其应用

农业高科技企业成长机会包括农业高新技术研发和市场推广,是一个系列递进买方期权。其价值是农业高科技企业价值的核心部分。本文利用二项式分布模型构建了时间和概率因素下成长机会的期权形式价值量化模型,总结了农业高科技企业的期权性质及其特点,并以此为基础,进一步讨论了成长机会价值量化模型在农业高科技企业价值评估中的应用。