A Tiered Framework for Risk‐Relevant Characterization and Ranking of Chemical Exposures: Applications to the National Children's Study (NCS)

A challenge for large‐scale environmental health investigations such as the National Children's Study (NCS), is characterizing exposures to multiple, co‐occurring chemical agents with varying spatiotemporal concentrations and consequences modulated by biochemical, physiological, behavioral, socioeconomic, and environmental factors. Such investigations can benefit from systematic retrieval, analysis, and integration of diverse extant information on both contaminant patterns and exposure‐relevant factors. This requires development, evaluation, and deployment of informatics methods that support flexible access and analysis of multiattribute data across multiple spatiotemporal scales. A new “Tiered Exposure Ranking” (TiER) framework, developed to support various aspects of risk‐relevant exposure characterization, is described here, with examples demonstrating its application to the NCS. TiER utilizes advances in informatics computational methods, extant database content and availability, and integrative environmental/exposure/biological modeling to support both “discovery‐driven” and “hypothesis‐driven” analyses. “Tier 1” applications focus on “exposomic” pattern recognition for extracting information from multidimensional data sets, whereas second and higher tier applications utilize mechanistic models to develop risk‐relevant exposure metrics for populations and individuals. In this article, “tier 1” applications of TiER explore identification of potentially causative associations among risk factors, for prioritizing further studies, by considering publicly available demographic/socioeconomic, behavioral, and environmental data in relation to two health endpoints (preterm birth and low birth weight). A “tier 2” application develops estimates of pollutant mixture inhalation exposure indices for NCS counties, formulated to support risk characterization for these endpoints. Applications of TiER demonstrate the feasibility of developing risk‐relevant exposure characterizations for pollutants using extant environmental and demographic/socioeconomic data.     

我国社区矫正工作社会化模式的建构——基于社区矫正工作目标的分析

社区矫正是社会化的刑罚执行方式,但从实践运作看,我国社区矫正的社会化程度依然不够,没有最大效度地达到社区矫正的目标.本文在对社区矫正工作目标进行分析的基础上,提出了我国社区矫正工作的社会化模式:基于责任共担的社区服刑环境建设、基于社会工作方法的个案矫正模式、基于社会人力资源的社会帮教工作.     

REVISITING THE AGENT OF SOCIAL CONTROL ROLE: IMPLICATIONS FOR SUBSTANCE ABUSE TREATMENT

The agent of social control role and its responsibilities and goals provide an important function in social work practice. Workers in varied positions often combine this role with others that define the profession. Yet in the not too distant past, a debate arose as to whether this role, focusing on promoting and protecting the general welfare of society, could be congruent with also fostering the improved functioning and self‐determination of individual clients. Periodically, this topic emerges to challenge the appropriateness of these dual activities in satisfactorily and equitably serving both constituents.

Within the field of substance abuse, court‐mandated referrals have established a need for practitioners to perform social control tasks to monitor and report clients' compliance with and progress in treatment. This has created a conflict for many who consider their practice to be client‐centered. This article will explore the dilemmas experienced in attempting to simultaneously carry out both roles and the guidance provided from the National Association of Social Workers (NASW) Code of Ethics. In addition, proposed strategies to reduce the duality of difficulties will be summarized.     

《周礼》的生态伦理系统思想

《周礼》以取法于天、以礼为治的思想为基础,形成了一套较为完整的生态伦理思想系统,其中包括完备的价值基础、伦理制度和具体的伦理原则。其保护对象主要有土地、山林川泽、矿藏及其他自然资源。《周礼》是世界上最早提到环境保护伦理法规的有系统的著作,其中的思想及措施总结了当时的生态伦理实践经验,对后世的生态伦理思想产生了深远的影响。     

An Ecological Model for Quantitative Risk Assessment for Schistosomiasis: The Case of a Patchy Environment in the Coastal Tropical Area of Northeastern Brazil

We developed a stochastic model for quantitative risk assessment for the Schistosoma mansoni (SM) parasite, which causes an endemic disease of public concern. The model provides answers in a useful format for public health decisions, uses data and expert opinion, and can be applied to any landscape where the snail Biomphalaria glabrata is the main intermediate host (South and Central America, the Caribbean, and Africa). It incorporates several realistic and case‐specific features: stage‐structured parasite populations, periodic praziquantel (PZQ) drug treatment for humans, density dependence, extreme events (prolonged rainfall), site‐specific sanitation quality, environmental stochasticity, monthly rainfall variation, uncertainty in parameters, and spatial dynamics. We parameterize the model through a real‐world application in the district of Porto de Galinhas (PG), one of the main touristic destinations in Brazil, where previous studies identified four parasite populations within the metapopulation. The results provide a good approximation of the dynamics of the system and are in agreement with our field observations, i.e., the lack of basic infrastructure (sanitation level and health programs) makes PG a suitable habitat for the persistence and growth of a parasite metapopulation. We quantify the risk of SM metapopulation explosion and quasi‐extinction and the time to metapopulation explosion and quasi‐extinction. We evaluate the sensitivity of the results under varying scenarios of future periodic PZQ treatment (based on the Brazilian Ministry of Health's plan) and sanitation quality. We conclude that the plan might be useful to slow SM metapopulation growth but not to control it. Additional investments in better sanitation are necessary.     

上海生态文明建设的激励和约束机制研究

生态文明建设是一项系统工程,需要通过整体推进,构筑规划、建设、管理、技术、产业、社会和合作协同发展的综合体系。未来上海应以建立和完善市场机制为核心,以法律机制为前提,以政府监管机制为保障,以能力建设机制为基础,以社会参与机制为监督,按照"引逼结合、多方合力、突出重点、先行先试"的原则,加快上海生态文明建设机制创新。主要途径有:完善碳排放交易试点,建立长效市场机制;推进分布式能源应用,提高清洁能源比重;加快新能源汽车推广,优化交通能源结构;培育发展再制造产业,推广先进制造理念。     

Engaging with Comparative Risk Appraisals: Public Views on Policy Priorities for Environmental Risk Governance

Communicating the rationale for allocating resources to manage policy priorities and their risks is challenging. Here, we demonstrate that environmental risks have diverse attributes and locales in their effects that may drive disproportionate responses among citizens. When 2,065 survey participants deployed summary information and their own understanding to assess 12 policy‐level environmental risks singularly, their assessment differed from a prior expert assessment. However, participants provided rankings similar to those of experts when these same 12 risks were considered as a group, allowing comparison between the different risks. Following this, when individuals were shown the prior expert assessment of this portfolio, they expressed a moderate level of confidence with the combined expert analysis. These are important findings for the comprehension of policy risks that may be subject to augmentation by climate change, their representation alongside other threats within national risk assessments, and interpretations of agency for public risk management by citizens and others.     

种次号作为书次号时辅助区分号的设置与应用

本文论述在以种次号作为书次号时如何合理使用辅助区分号，使得馆藏排架更加科学合理，方便读者利用。     

“生态整体主义”对文学批评的意义

“生态整体主义”对文学批评的意义表现在文学批评标准和文学批评理论思维方式这两个方面；是对这两个方面可能存在的“中心论”与“二元论”的超越!只有不预设中心，才能平等对待不同的文学批评对象；只有将线性的、孤立的、有序的思维拓展到整体论的、复杂性的思维，文学批评才可能具有创新意味。     

区块链与法律的互动:挑战、规制与融合

区块链技术的迅速崛起在刑法、合同法、数据保护法和公司法等多个法律领域对法律带来了挑战,对区块链技术进行适当的法律规制是必要且可行的,应当采取试验性监管、自我监管、共同监管、类型化监管等策略对区块链实施适度、科学的法律规制,实现技术创新和公共政策的双赢。与此同时,区块链技术也与法律发生着融合,其不仅可作为法律科技辅助法律的实施,还在一定程度上补充乃至替代传统法律。区块链与法律的深度融合使法律呈现代码化的趋势,将使传统法律发生颠覆性重构。