Bayes shrinkage estimator for consistency assessment of treatment effects in multi-regional clinical trials

The primary objective of a multi-regional clinical trial is to investigate the overall efficacy of the drug across regions and evaluate the possibility of applying the overall trial result to some specific region. A challenge arises when there is not enough regional sample size. We focus on the problem of evaluating applicability of a drug to a specific region of interest under the criterion of preserving a certain proportion of the overall treatment effect in the region. We propose a variant of James-Stein shrinkage estimator in the empirical Bayes context for the region-specific treatment effect. The estimator has the features of accommodating the between-region variation and finiteness correction of bias. We also propose a truncated version of the proposed shrinkage estimator to further protect risk in the presence of extreme value of regional treatment effect. Based on the proposed estimator, we provide the consistency assessment criterion and sample size calculation for the region of interest. Simulations are conducted to demonstrate the performance of the proposed estimators in comparison with some existing methods. A hypothetical example is presented to illustrate the application of the proposed method.     

简析职校生职业生涯规划中的常见误区

"职业教育就是就业教育"。进行职业生涯规划,就是为自己构筑人生的宏伟大厦。职校生因生源基础、生活阅历以及客观环境等局限,对自我和社会往往缺乏全面、正确的认识,不能审时度势、科学抉择,正确规划自己的职业人生,他们在生涯规划时易陷进一些误区。明确这些误区,旨在正视生涯教育,启迪职校生的心灵成长。     

小议歌曲在法语教学中的运用

音乐能够调节情绪、激发兴趣,促进理解、增强记忆。法语歌曲较好地融合了语音、语言和文化知识,如果选择恰当、教学设计合理,在遵循法语语言知识的学习和各项语言技能训练的前提下,将法语歌曲作为语言学习的辅助材料,既可增加教学内容的趣味性,又可提高教学方式的灵活性。     

社会主义生态文明建设的重要内容: 生态消费模式

当前，我国消费伴随着经济的快速发展日益被异化为“病态式消费”模式，这使得国民经济的协调发展遭到了严重破坏，甚至生态系统也面临着崩溃的危险。我国新富群体缺乏正确的消费观念，加上西方消费主义影响，引发了诸多的社会问题。实践证明，只有树立正确的消费观念、克制消费欲望、调整消费行为，才能建立生态消费模式，才能符合社会主义生态文明的要求，实现人与自然的协调发展。     

德、位张力与先秦儒家的性命之学——对楚简《唐虞之道》第14至29号简的思想解读

文章系统解读了楚简《唐虞之道》第14至29号简的思想内涵及脉络,认为这部分简文首先通过尧成为天子之原因的追问,突出了德与位的张力问题,即在应然之理上,有位必当有德,但就实然之事看,有德未必有位.简文对这一德位张力有两个层面的解决方案:一方面,要求有德无位者全力修德,谨守性命,安于时命,养成恒常如一的圆满德行,从而能在得位而治时能“利天下而弗利”；另一方面,要求有位者透悟性命之正,从而能主动尚德授贤、退而养生,这既能使贤者居位而利天下,又能退而养生以自利.简文将“七十致政”之礼普遍化,试图断绝天子终身制的构想,也具有深刻的政治哲学意义.     

Comparing diagnostic tests: test of hypothesis for likelihood ratios

Likelihood ratios (LRs) are used to characterize the efficiency of diagnostic tests. In this paper, we use the classical weighted least squares (CWLS) test procedure, which was originally used for testing the homogeneity of relative risks, for comparing the LRs of two or more binary diagnostic tests. We compare the performance of this method with the relative diagnostic likelihood ratio (rDLR) method and the diagnostic likelihood ratio regression (DLRReg) approach in terms of size and power, and we observe that the performances of CWLS and rDLR are the same when used to compare two diagnostic tests, while DLRReg method has higher type I error rates and powers. We also examine the performances of the CWLS and DLRReg methods for comparing three diagnostic tests in various sample size and prevalence combinations. On the basis of Monte Carlo simulations, we conclude that all of the tests are generally conservative and have low power, especially in settings of small sample size and low prevalence.     

清末民初自由报人林白水的办报思想与实践

在近代中国暗弱的年代里,林白水将国家的兴盛和民族的前途寄托于普通民众身上,投身报业,主持、参与或创办了十余种报刊,用浅易的白话文积极宣传民主、启蒙思想,揭露列强侵凌的岌岌时局以及封建统治者和北洋军阀政客的贪渎行径,表现出极浓烈的平民意识和强烈的爱国情怀。尽管在其行程中,有一段瑕疵,但那是特殊境遇里的短暂迷失,就其一生看,他未失去一个报人和杰出知识人的良知。     

基于建构主义学习理论的网络课程建设及其应用——以“经济法”课程为例

商科专业＂经济法＂网络课程的建设,应基于建构主义学习理论,以发挥学生学科优势为基础;以培养应用型、复合型人才为目标;遵循内容体系化、模块化原则和知识学习为手段、方法意识为目标原则,在具体应用中采取相应措施。如在网络课堂公布热点案例引起讨论,讲授难点、重点,提出分析问题的思路,创设学习情景,强化实践技能,并与职业考试接轨以拓宽学生的就业渠道等。这样可以保证网络课程的实际应用效果。     

民族文化元素在偶动画艺术创作中的应用

本文探讨了偶动画艺术创作与民族文化之间的关系,阐述了民族文化元素在偶动画创作中的具体应用方式。从题材、内容、风格等多个方面着手,探究如何以创新的思维方式与偶动画表现形式相结合,创造出更多具有影响力的国际性偶动画作品。     

竞业限制条款法律适用及其完善

企业基于商业秘密之保护和维持永续竞争力,通常要求员工签订竞业限制协议或条款,其中涉及商业秘密保护权和员工劳动就业权的冲突。因我国目前相关法律规定零散而不成体系,因此应合理构建竞业限制条款的具体制度,规定一般员工的法定竞业限制义务,明确竞业限制的主体、适用范围、经济补偿、违约责任、期限等,准确理解违反竞业限制义务的责任构成及其责任形式是实现权利冲突的合理解决和劳资双方共赢的最佳途径。