管-管相贯线机器人焊接枪体姿态的拟合

针对管一管相贯线机器人焊接焊缝,提出了其具有不一致的角焊缝和焊接接头深度的特点,指出了管一管相贯线 的全位置焊接对焊接机器人的要求,通过MATLAB分段拟合的方法得到机器人坐标系下6个轴的坐标与工件坐标系坐 标的关系曲线,即焊接机器人的枪体姿态,为后续通过对焊接机器人焊枪姿态的合理设定和工艺参数的优化来保证相贯 线焊缝的成形质量的研究奠定基础。     

季节性冻土地区保温护道路基温度场数值模拟

研究路基及周围土体温度的分布规律是分析季节性冻土地区路基稳定性的重要基础,结合哈齐客专DK221+150断面3 a的现场监测数据,分析了天然地表及路基不同位置的地温分布规律;建立温度场的仿真模型,研究温度沿深度方向的变化规律;利用实测数据验证模型,分析保温护道高度对路基温度场的影响。现场监测和模拟计算结果表明：护道对路基的边坡下部和坡脚处影响较大,能够有效减小冻深,但对路基中心的温度场影响不大。     

Likelihood approach for evaluating bioequivalence of highly variable drugs

Bioequivalence (BE) is required for approving a generic drug. The two one‐sided tests procedure (TOST, or the 90% confidence interval approach) has been used as the mainstream methodology to test average BE (ABE) on pharmacokinetic parameters such as the area under the blood concentration‐time curve and the peak concentration. However, for highly variable drugs (%CV > 30%), it is difficult to demonstrate ABE in a standard cross‐over study with the typical number of subjects using the TOST because of lack of power. Recently, the US Food and Drug Administration and the European Medicines Agency recommended similar but not identical reference‐scaled average BE (RSABE) approaches to address this issue. Although the power is improved, the new approaches may not guarantee a high level of confidence for the true difference between two drugs at the ABE boundaries. It is also difficult for these approaches to address the issues of population BE (PBE) and individual BE (IBE). We advocate the use of a likelihood approach for representing and interpreting BE data as evidence. Using example data from a full replicate 2 × 4 cross‐over study, we demonstrate how to present evidence using the profile likelihoods for the mean difference and standard deviation ratios of the two drugs for the pharmacokinetic parameters. With this approach, we present evidence for PBE and IBE as well as ABE within a unified framework. Our simulations show that the operating characteristics of the proposed likelihood approach are comparable with the RSABE approaches when the same criteria are applied. Copyright © 2014 John Wiley & Sons, Ltd.     

Monitoring and change-point estimation for spline-modeled non-linear profiles in phase II

In some applications of statistical quality control, quality of a process or a product is best characterized by a functional relationship between a response variable and one or more explanatory variables. This relationship is referred to as a profile. In certain cases, the quality of a process or a product is better described by a non-linear profile which does not follow a specific parametric model. In these circumstances, nonparametric approaches with greater flexibility in modeling the complicated profiles are adopted. In this research, the spline smoothing method is used to model a complicated non-linear profile and the Hotelling T² control chart based on the spline coefficients is used to monitor the process. After receiving an out-of-control signal, a maximum likelihood estimator is employed for change point estimation. The simulation studies, which include both global and local shifts, provide appropriate evaluation of the performance of the proposed estimation and monitoring procedure. The results indicate that the proposed method detects large global shifts while it is very sensitive in detecting local shifts.     

论党的三代领导核心对实事求是思想路线的贡献

实事求是是我们党的思想路线 ,党的三代领导核心对这一思想路线作出了不同的重要贡献。毛泽东是实事求是思想路线的首创者。邓小平将解放思想与实事求是结合起来 ,创造性地发展了实事求是的思想路线。江泽民坚持与时俱进、开拓创新 ,提出了“三个代表”重要思想 ,这是对实事求是思想路线的新拓展     

P-V图中准静态直线过程的研究

研究了P -V图中理想气体准静态直线过程的变化情况 ,应用两种不同的方法 ,证明了在直线过程中温度最高点与吸放热转换点并不相同 ,并讨论了直线过程的温度和热量转换问题 .     

滇黔桂联合开发国际旅游线路问题研究

滇黔桂地理上相互连接,旅游资源丰富且特色鲜明、互补性强。三省区联合开发国际旅游线路既有必要性,又有良好的资源、交通与产业发展基础。其关键问题是必须加强旅游基础设施的软硬件建设、合理选定联合开发的具体线路和以创新的思维与高起点来构建三省区联合开发国际旅游线路的运作机制。     

室内设计中点线面要素的应用研究

“设计”是一个经常使用的概念,设计是在明确目的指导下的有意识的创造。室内设计是人们在满足自身需求的基础上对建筑的内部空间进行合理的功能划分、技术创新,以及艺术上的审美观的综合设计。点、线、面是作为构成抽象形态造型的要素,空间构成的基本单位。在室内设计中,点、线、面处处可见,它们之间相互影响、相互陪衬、相互烘托、相互存在、相互作用。文章从室内设计的风格、室内陈设的研究出发,对室内设计中点、线、面的运用进行思考分析。     

马克思主义群众观与社会主义的实践发展

马克思主义关于人的本质理论、群众观点、科学社会主义理论的形成和发展,不仅是理论探索的结果,而且更是调查研究和实践的结晶。文章立足于客观史实,以时间为导线,以马克思关于人的本质学说为切入点,阐述了马克思主义群众观的诞生和发展。结合我国的具体国情,介绍了马克思主义群众观和科学社会主义理论在不同历史时期对中国发展的影响,总结出只有坚持群众路线中国的改革和建设才能取得成功的科学论断。     

大陆儒教派的学术理路评析

大陆"儒教是教"说的提出引发了关于儒学是否为宗教问题的长期争论,有必要对其观点和学理进行宏观的审视和客观的评价。大陆儒教派一是受西方学者研究儒教的影响,以西方近代科学主义的理路判释儒教,以西方宗教来比附儒教;二是在马克思主义教条化及其长期的浸润下,以二元对抗思维指导学术研究,使儒教研究步入误区;三是在西方实体主义的影响下,以儒教为中国文化的本质存在,并把儒教对象化、断裂化、抽象化、绝对化。