日本研讨自然辩证法的思想方法

日本是开展自然辩证法研究比较早的国家之一 ,并在研讨自然辩证法方面形成了许多富有启发性的思想方法。可将其概括为 :自由论争的思想方法、“具体化”的思想方法、发展的思想方法、联盟的思想方法     

家族企业管理机制创新探析

改革开放以来 ,我国私营经济获得了长足的发展 ,并为我国经济和社会发展做出了重要贡献 ,成为社会主义市场经济的重要组成部分。但随着市场外在条件和社会经济发展格局的变化 ,作为私营资本形式之一的家族企业 ,其自身的不适应性逐步凸现出来。克服家族式管理的不足 ,转换管理机制和管理方式 ,通过资本市场使家族企业完成由家庭化向专业化、由宗法化向市场化的转变 ,是使其真正做大做强的必由之路     

证券投资管理专业人才需求分析与人才规格设计

随着经济体制改革的深化,社会经济生活中对投融资的需求日益旺盛,大中型企业转机建制、民营企业谋求发展将更加依赖资本市场,证券业因此成为我国新兴行业,证券人才需求不仅空间巨大,而且呈现明显的层次性,既需要高层次的决策者、管理者,更需要具有较强职业技能的管理、服务第一线的应用性人才。证券投资管理专业应据此确定人才培养目标和人才培养规格。     

Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols

In confirmatory clinical trials, the prespecification of the primary analysis model is a universally accepted scientific principle to allow strict control of the type I error. Consequently, both the ICH E9 guideline and the European Medicines Agency (EMA) guideline on missing data in confirmatory clinical trials require that the primary analysis model is defined unambiguously. This requirement applies to mixed models for longitudinal data handling missing data implicitly. To evaluate the compliance with the EMA guideline, we evaluated the model specifications in those clinical study protocols from development phases II and III submitted between 2015 and 2018 to the Ethics Committee at Hannover Medical School under the German Medicinal Products Act, which planned to use a mixed model for longitudinal data in the confirmatory testing strategy. Overall, 39 trials from different types of sponsors and a wide range of therapeutic areas were evaluated. While nearly all protocols specify the fixed and random effects of the analysis model (95%), only 77% give the structure of the covariance matrix used for modeling the repeated measurements. Moreover, the testing method (36%), the estimation method (28%), the computation method (3%), and the fallback strategy (18%) are given by less than half the study protocols. Subgroup analyses indicate that these findings are universal and not specific to clinical trial phases or size of company. Altogether, our results show that guideline compliance is to various degrees poor and consequently, strict type I error rate control at the intended level is not guaranteed.     

A Test for Instrument Validity

This paper develops a specification test for instrument validity in the heterogeneous treatment effect model with a binary treatment and a discrete instrument. The strongest testable implication for instrument validity is given by the condition for nonnegativity of point‐identifiable compliers' outcome densities. Our specification test infers this testable implication using a variance‐weighted Kolmogorov–Smirnov test statistic. The test can be applied to both discrete and continuous outcome cases, and an extension of the test to settings with conditioning covariates is provided.     

Bayesian Conditional Mean Estimation in Log‐Normal Linear Regression Models with Finite Quadratic Expected Loss

Log‐normal linear regression models are popular in many fields of research. Bayesian estimation of the conditional mean of the dependent variable is problematic as many choices of the prior for the variance (on the log‐scale) lead to posterior distributions with no finite moments. We propose a generalized inverse Gaussian prior for this variance and derive the conditions on the prior parameters that yield posterior distributions of the conditional mean of the dependent variable with finite moments up to a pre‐specified order. The conditions depend on one of the three parameters of the suggested prior; the other two have an influence on inferences for small and medium sample sizes. A second goal of this paper is to discuss how to choose these parameters according to different criteria including the optimization of frequentist properties of posterior means.     

基于核心制造规范的外包决策模型及实证研究

本文将制造规范概念引入外包决策,从考虑企业长期绩效和长期竞争力的角度提出了一个以制造规范核心度和流失度为控制变量的二维外包决策模型。决策模型将外包环境分为九种类型,涵盖了从内部制造、各种形式的外包,到简单采购等所有"买或做"的决策,尤其是对介于自制与简单采购之间灰色地带的外包,给出了考虑提供制造规范主体和供应商类型的不同类型合作和联盟治理结构策略。对四个不同类型的企业典型产品近1000个零件的外包决策进行了统计分析,实证了模型的有效性。模型对现实世界观察到的制造企业由于没有按照其中规律行事而导致失败的原因做出了合理而明确解释。     

实践性·具体性·系统性--全面贯彻"三个代表"重要思想的方法论原则探论

要使"三个代表"重要思想真正成为全党在实际工作中长期坚持的指导思想,就必须正确解决实现"三个代表"重要思想的科学方法论问题,切实按照马克思主义的实践性、具体性、系统性原则的要求,在贯彻"三个代表"重要思想过程中,始终做到"务实"与"务虚"、"共性"与"个性"、"部分"与"整体"的有机统一.