对开拓中医药成人高等教育潜在市场的思考

我国的成人高等教育 ,在实现从计划经济到市场经济转变后 ,出现了前所未有的竞争场面。作为行业性很强的中医药成人高等教育 ,要想生存和进一步发展 ,必须在积极参加市场竞争的同时 ,根据自身的优势和特点 ,从社会发展的高度 ,大力开拓潜在市场 ,努力寻找中医药成人高等教育的发展空间     

On concurrence of several linear regressions and applications to problems of enzyme kinetics

In comparing several regressions E(y_ij) =α_i + β_ix_ij i = 1, 2, ..., k, j = 1,2, ..., n_i, researchers are generally interested in the following five problems: whether they have (1) equal slope, (2) equal intercept, (3) coincidence, (4) common intersection on X-axis, and (5) common intersection on (X,Y) - plane. Problems (1) - (3) can be put into the framework of the general linear hypothesis and the F-test can be used. However, problems (4) and (5) cannot be put into the general linear hypothesis because they are ratios of parameters. Hence, in this paper we consider the generalized likelihood ratio test for hypothesis testing. An application to an enzyme kinetics problem in Aniline Metabolism is demonstrated     

Testing bioequivalence for multiple formulations with power and sample size calculations

Bioequivalence (BE) trials play an important role in drug development for demonstrating the BE between test and reference formulations. The key statistical analysis for BE trials is the use of two one‐sided tests (TOST), which is equivalent to showing that the 90% confidence interval of the relative bioavailability is within a given range. Power and sample size calculations for the comparison between one test formulation and the reference formulation has been intensively investigated, and tables and software are available for practical use. From a statistical and logistical perspective, it might be more efficient to test more than one formulation in a single trial. However, approaches for controlling the overall type I error may be required. We propose a method called multiplicity‐adjusted TOST (MATOST) combining multiple comparison adjustment approaches, such as Hochberg's or Dunnett's method, with TOST. Because power and sample size calculations become more complex and are difficult to solve analytically, efficient simulation‐based procedures for this purpose have been developed and implemented in an R package. Some numerical results for a range of scenarios are presented in the paper. We show that given the same overall type I error and power, a BE crossover trial designed to test multiple formulations simultaneously only requires a small increase in the total sample size compared with a simple 2 × 2 crossover design evaluating only one test formulation. Hence, we conclude that testing multiple formulations in a single study is generally an efficient approach. The R package MATOST is available at https://sites.google.com/site/matostbe/ . Copyright © 2012 John Wiley & Sons, Ltd.     

恒温平滑肌槽在生理学、药理学实验教学中的应用

以生理学、药理学实验中的药物对离体小肠平滑肌收缩性的影响实验为例,介绍了HW-400E恒温平滑肌槽的功能特点、使用方法和注意事项,以供生理学、药理学实验教学和科研工作者参考。     

中医药非物质文化遗产保护的政策法律措施

关于中医药的存废已成为社会热点问题。无论取消或保护的呼声谁高谁低，各方人数有多少．这都是一种巨大的悲哀。这种没有标准的、不分是非的争论，既非政府观点，也非民意体现，纯属医学圈内人士专业之间的成见加上圈外人的“无知”盲从“现代”，形成对宝贵传统文化资源的群体性破坏。国家应当通过综合措施引导、规范，达到保护和充分利用的效果。     

马克思主义方法论视角下的现代中医中药

讨论中医中药的发展问题应当以公认的方法论为基础。以马克思主义方法论考察,中医中药没有理由、没有必要、更没有可能被废除或告别。中医中药的存在对人类健康事业,甚至对西医的发展都是有益的。同时,现代中医中药应当遵循否定之否定规律,对古代中医理论予以充分的扬弃。     

人文属性是中医学的最大特色

医学具有自然科学和人文科学的双重属性 ,而中医学的人文属性更加强烈。从本质上讲 ,中医学实际上是一门兼有自然科学属性的人文学科。充分肯定中医学的人文属性有助于全面地把握中医理论体系的本质 ,也有助于给现代科学研究中医学一个正确的定位。中医学应当冲出唯科学主义的阴影。     

兽医药理学省级精品课程建设的实践与体会

精品课程建设是提高高等院校教学质量,加快教学改革工程建设的重要举措。兽医药理学课程组经过提高师资队伍素质,优化教学内容及课程体系,创新教学方法与手段,完善教材配套体系,组建试题库和构建网络信息平台等建设与实践,将兽医药理学课程建设成为黑龙江省级精品课程,收到了良好的教学效果。     

牡丹皮有效成分的药理及分析方法研究进展

在查阅有关牡丹皮药材及其复方制剂相关文献的基础上,概括分析了牡丹皮有效成分的药理及成分分析方法的研究进展,为进一步研究牡丹皮及其复方制剂提供了参考.     

氨氯地平在高血压治疗中的应用与临床药理

新型二氢吡啶类药物—氨氯地平与常用的钙拮抗剂硝苯地平相比 ,除了具有高度的血管选择性外 ,兼有半衰期长、作用持久、不良反应少而轻、服用方便等特点 .治疗作用的机制和药动学特点进展迅速 ,尤其在降压疗效 ,老年性高血压 ,高血压合并糖尿病 ,联合用药治疗高血压等方面发挥着重要的作用