Probabilistic population projections for countries with generalized HIV/AIDS epidemics

In 2015, the United Nations (UN) issued probabilistic population projections for all countries up to 2100, by simulating future levels of total fertility and life expectancy and combining the results using a standard cohort component projection method. For the 40 countries with generalized HIV/AIDS epidemics, the mortality projections used the Spectrum/Estimation and Projection Package (EPP) model, a complex, multistate model designed for short-term projections of policy-relevant quantities for the epidemic. We propose a simpler approach that is more compatible with existing UN projection methods for other countries. Changes in life expectancy are projected probabilistically using a simple time series regression and then converted to age- and sex-specific mortality rates using model life tables designed for countries with HIV/AIDS epidemics. These are then input to the cohort component method, as for other countries. The method performed well in an out-of-sample cross-validation experiment. It gives similar short-run projections to Spectrum/EPP, while being simpler and avoiding multistate modelling.     

A Simulation Study of Some Biasing Parameters for the Ridge Type Estimation of Poisson Regression

This article proposes several estimators for estimating the ridge parameter k based on Poisson ridge regression (RR) model. These estimators have been evaluated by means of Monte Carlo simulations. As performance criteria, we have calculated the mean squared error (MSE), the mean value, and the standard deviation of k. The first criterion is commonly used, while the other two have never been used when analyzing Poisson RR. However, these performance criteria are very informative because, if several estimators have an equal estimated MSE, then those with low average value and standard deviation of k should be preferred. Based on the simulated results, we may recommend some biasing parameters that may be useful for the practitioners in the field of health, social, and physical sciences.     

Price bias and common practice in option pricing

Generally, the semiclosed-form option pricing formula for complex financial models depends on unobservable factors such as stochastic volatility and jump intensity. A popular practice is to use an estimate of these latent factors to compute the option price. However, in many situations this plug-and-play approximation does not yield the appropriate price. This article examines this bias and quantifies its impacts. We decompose the bias into terms that are related to the bias on the unobservable factors and to the precision of their point estimators. The approximated price is found to be highly biased when only the history of the stock price is used to recover the latent states. This bias is corrected when option prices are added to the sample used to recover the states' best estimate. We also show numerically that such a bias is propagated on calibrated parameters, leading to erroneous values. The Canadian Journal of Statistics 48: 8–35; 2020 © 2019 Statistical Society of Canada     

Robust Designs in Generalized Linear Models: A Quantile Dispersion Graphs Approach

This article studies design selection for generalized linear models (GLMs) using the quantile dispersion graphs (QDGs) approach in the presence of misspecification in the link and/or linear predictor. The uncertainty in the linear predictor is represented by a unknown function and estimated using kriging. For addressing misspecified link functions, a generalized family of link functions is used. Numerical examples are shown to illustrate the proposed methodology.     

Horwitz's rule, transforming both sides and the design of experiments for mechanistic models

Summary. The paper develops methods for the design of experiments for mechanistic models when the response must be transformed to achieve symmetry and constant variance. The power transformation that is used is partially justified by a rule in analytical chemistry. Because of the nature of the relationship between the response and the mechanistic model, it is necessary to transform both sides of the model. Expressions are given for the parameter sensitivities in the transformed model and examples are given of optimum designs, not only for single-response models, but also for experiments in which multivariate responses are measured and for experiments in which the model is defined by a set of differential equations which cannot be solved analytically. The extension to designs for checking models is discussed.     

Bayesian inference for a discretely observed stochastic kinetic model

The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient.     

多元主体环境责任协同水平的地区差异与动态演进

基于中国30个省、自治区、直辖市（由于数据原因暂未包含西藏和港澳台地区）,构建多元主体环境责任协同水平指标体系,运用复合系统协同度模型,定量测算多元主体环境责任协同水平,并利用Dagum基尼系数和核密度估计方法分析其空间格局和动态演进过程。研究结果表明：中国各地多元主体环境责任协同水平整体偏低,呈现出逐年上升的趋势;环境责任协同水平空间分布的总体差异呈波动扩大趋势,地区间差距是总体差异的主要空间来源;环境责任协同水平的地区差异呈上升态势,东部、中部和西部三个地区的环境责任协同水平呈两极分化态势。     

Circuit optimization via sequential computer experiments: design of an output buffer

In electrical engineering, circuit designs are now often optimized via circuit simulation computer models. Typically, many response variables characterize the circuit's performance. Each response is a function of many input variables, including factors that can be set in the engineering design and noise factors representing manufacturing conditions. We describe a modelling approach which is appropriate for the simulator's deterministic input–output relationships. Non-linearities and interactions are identified without explicit assumptions about the functional form. These models lead to predictors to guide the reduction of the ranges of the designable factors in a sequence of experiments. Ultimately, the predictors are used to optimize the engineering design. We also show how a visualization of the fitted relationships facilitates an understanding of the engineering trade-offs between responses. The example used to demonstrate these methods, the design of a buffer circuit, has multiple targets for the responses, representing different trade-offs between the key performance measures.     

中国人口老龄化的地区差异分析

本文基于1990—2013年省际面板数据，以老年人口比重作为老龄化指标，采用基尼系数分解方法和Kernel密度估计方法，实证分析了中国人口老龄化的地区差异及其动态演进过程。研究结果表明：中国人口老龄化在地区分布上呈现出明显的非均衡特征；基尼系数测算及其分解结果表明，人口老龄化的地区差异总体上呈现波动缩小趋势；2004年以前，地区间差距和超变密度交替成为总体地区差异的主要来源，2004年以后，超变密度成为总体差异的主要来源。 Kernel密度估计显示，老龄化程度不断加深，地区差异呈波动趋势。     

An optional randomized response model for estimating a rare sensitive attribute using Poisson distribution

The crux of this article is to estimate the mean of the number of persons possessing a rare sensitive attribute based on the Mangat (1991 Mangat, N.S. (1991). An optional randomized response sampling technique using non–stigmatized attribute. Statistica. 51(4):595–602. [Google Scholar]) randomization device by utilizing the Poisson distribution in simple random sampling and stratified sampling. Properties of the proposed randomized response (RR) model have been studied along with recommendations. It is also shown that the proposed model is more efficient than that of Land et al. (2011 Land, M., Singh, S., Sedory, S.A. (2011). Estimation of a rare attribute using Poisson distribution. Statistics. 46(3):351–360.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) in simple random sampling and that of Lee et al. (2013 Lee, G.S., Uhm, D., Kim, J.M. (2013). Estimation of a rare sensitive attribute in stratified sampling using Poisson distribution. Statistics. 47(3):575–589.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) in stratified random sampling when the proportion of persons possessing a rare unrelated attribute is known. Numerical illustrations are also given in support of the present study.