Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

When a candidate predictive marker is available, but evidence on its predictive ability is not sufficiently reliable, all‐comers trials with marker stratification are frequently conducted. We propose a framework for planning and evaluating prospective testing strategies in confirmatory, phase III marker‐stratified clinical trials based on a natural assumption on heterogeneity of treatment effects across marker‐defined subpopulations, where weak rather than strong control is permitted for multiple population tests. For phase III marker‐stratified trials, it is expected that treatment efficacy is established in a particular patient population, possibly in a marker‐defined subpopulation, and that the marker accuracy is assessed when the marker is used to restrict the indication or labelling of the treatment to a marker‐based subpopulation, ie, assessment of the clinical validity of the marker. In this paper, we develop statistical testing strategies based on criteria that are explicitly designated to the marker assessment, including those examining treatment effects in marker‐negative patients. As existing and developed statistical testing strategies can assert treatment efficacy for either the overall patient population or the marker‐positive subpopulation, we also develop criteria for evaluating the operating characteristics of the statistical testing strategies based on the probabilities of asserting treatment efficacy across marker subpopulations. Numerical evaluations to compare the statistical testing strategies based on the developed criteria are provided.     

乡土社会语境下梅山武术的生态发展

中国乡土武术文化的生存形态可分为原生形态、次生形态以及艺术形态。在现代中国,社会变迁主要体现在社会再生产土壤、社会再生产方式、社会再生产功能等方面的变迁,致使中国乡土武术文化的生态传承内容、动力、方式及评判标准发生变化。因此,中国乡土武术文化发展出路在于自身的文化内涵的拓深和增值,以适应民众正在或已经改变的文化需求。     

雄安新区科技企业创新能力评价研究

科技企业是实现科技创新的驱动者和科技成果转化的重要载体,也是推动研究开发的重要参与者,科学评价科技企业创新能力有助于企业自身不断发展壮大。在分析国内外新区科技企业创新驱动发展相关理论研究的基础上,从研发投入、研发基础、研发效益和现代科技四个角度,运用层次分析法构建科技企业创新能力评价系统,并通过实证分析说明评价系统的可靠性;根据评价系统测算出现阶段雄安新区科技企业创新能力,通过与成熟新区科技企业的比较,发现其短板和不足,力图为决策者科学合理评价、管理科技企业创新发展提供有益参考。     

影子银行、地方政府债务及金融发展动态关系研究——基于省级面板VAR模型

基于2004—2017年中国省级面板数据,运用面板向量自回归(PVAR)模型,使用系统GMM估计、脉冲响应函数、方差分解以及格兰杰因果关系检验等方法分析了影子银行、地方政府债务及金融发展之间的动态关系.结果表明:影子银行、地方政府债务与金融发展水平三者之间存在动态耦合关系.在地方政府融资能力受到约束的情况下,影子银行为地方政府提供了多元的融资方式,在增加政府融资能力的同时提升了政府债务水平;而地方政府债务需求显著推动了影子银行规模的快速发展.同时,影子银行过度扩张危害了金融市场的健康发展,降低金融发展水平,继而使地方政府的融资渠道受到约束.但金融发展并不能有效约束影子银行规模,原因在于,政府融资需求是影子银行的主要动力,若不能控制地方政府的借贷行为则无法从源头解决问题.监管机构在去杠杆的过程中,应该综合考虑影子银行与地方政府债务、金融发展之间的动态关系,如此才能够实现预期的政策效果.     

乡村振兴视域中的农民主体作用、制约因素及路径选择——基于湖南岳阳乡村的调查与思考

农民是农业和农村的主体,也是乡村振兴的内生因素,发挥农民主体作用对实施乡村振兴战略意义重大。当前农民对乡村振兴关注度和支持度较高,农民的主体作用发挥成为乡村振兴的根本动力。但现实中,农民主体作用也受到诸如农业综合效益较低、农民自身思想文化和能力素质不高、管理机制滞后及基础条件薄弱等多方面的因素制约,需要党委、政府综合施策,采取完善乡村治理、健全政策扶持、建立引导机制、补齐短板缺陷、加强培育培训等一系列政策措施,尊重、引导、激励和支持农民自我管理、自我发展,激发农民的主动性、积极性、创造性。     

Having it all overseas: Aid workers and the international division of reproductive labour

This article examines the dynamics of power and privilege at work in international development through the prism of domestic service for expat aid workers in developing countries. Drawing on ethnographic fieldwork amid aid workers and their domestic staff in Dakar, Senegal, I argue that access to affordable care work greatly enhances the lives of women who work overseas in development. The postcolonial underdevelopment and poverty that aid work addresses is paradoxically critical to the aid workers' own access to affordable care, family balance and the means to do their jobs. I put this insight into the larger scholarly conversation about domestic work and global inequality, including on the Global Care Chain.     

页岩气开发环境风险的法律规制思考

目前，我国在页岩气开发的环境保护方面存在着大量的法律空白，往往只能参照环境保护法和矿产资源法中的相关规定进行规制，无法有效解决页岩气开发暴露出来的环境问题。页岩气开发环境风险的法律规制，核心目的就是解决当前页岩气开发中的环境风险，促进页岩气开发与环境保护相协调，实现能源开发的可持续发展。在页岩气开发环境风险的法律规制方面，英美两国已经探索出一些经验和制度。积极借鉴国外有益经验，努力改进和完善我国应对页岩气开发环境风险的法律规制，对实现我国页岩气开采的经济效益、社会效益和环境效益三者的统一具有重要的现实意义。     

信息技术与高中数学课程整合探究

信息技术与数学课程整合已成为必然趋势,各种教学辅助软件的出现使教师应接不暇。数学软件Maple凭借其简单的操作和强大的功能等优势被越来越多的数学教师作为辅助教学软件。本文用数学实验的方法介绍了Maple在高中数学教学中的几个应用实例,并对信息技术与课程整合与传统教学法之间的优缺点进行了比较。     

两汉孙吴会稽郡诸部都尉考

The commander was mainlu in charge of the army in the local administration system during the Han Dynasty to the Sunwu Period. As the border prefectures were important in military defense, the armies of these prefectures were commonly divided into parts. Therefore, the army of Kuaiji Prefecture were divided into West Section Duwei, East Section Duwei and South Section Duwei. The West and East Section Duweis were founded for the purpose of suppressing the adherents of Yuyue as well as the Minyue and Ouyue people in the southeast coastline. In demand of securing the safety of the ship routes alongside the southeast coastline, the East Section Duwei migrated frequently within the area. In the meantime, the foundation of South Section Duwei was the result of the Sunwu government suppressing the local force and pillaging the labor resources in a partition background     

区块链技术在版权登记中的创新应用

随着数字版权时代的发展，作品的传播方式变得更加灵活，传播速度也更加迅捷。传统版权登记制度因存在登记成本较高、标准不一、泄露隐私等弊端，在实际应用中面临困境，区块链技术的出现为推动版权登记的适时发展提供了一种新思路。区块链技术应用于版权登记，其去中心化特质可以降低登记成本；分布式共享机制能够统一登记标准；难以篡改的性质能够提高登记的证明效力；弥补了既有版权登记制度的缺陷。同时，区块链技术利用自身特性建立新的版权信任机制，既能清晰地分配版权利益，又能创新传统的版权商业模式，推动版权市场的发展，最大化地利用版权的固有价值。区块链技术在与版权登记相结合的过程中，会出现一些技术上难以解决的问题，既无法对作品的独创性进行准确的判断，也无法发挥版权制度原有的公示力作用。因此，必须创新版权登记规则，加快制定区块链版权平台市场准入机制，并设置统一的监管机构，将区块链锁在版权制度的笼子里，防止出现滥用区块链技术的情形，以最终实现技术和法律的融合发展。