Geometric Method and Generalized Linear Models. Two Opposite Multiparametric Approaches Illustrated on a Sample of Pituitary Adenomas

We used two statistical methods to identify prognostic factors: a log-linear model (logistic and COX regression, based on the notions of linearity and multiplicative relative risk), and the CORICO method (ICOnography of CORrelations) based on the geometric significance of the correlation coefficient. We applied the methods to two different situations (a "case-control study' and a "historical cohort'). We show that the geometric exploratory tool is particularly suited to the analysis of small samples with a large number of variables. It could save time when setting up new study protocols. In this instance, the geometric approach highlighted, without preconceived ideas, the potential role of multihormonality in the course of pituitary adenoma and the unexpected influence of the date of tumour excision on the risk attached to haemorrhage.     

司空图《诗品》篇天人合一思维模式的原型追溯

以原型的方法对司空图《诗品》天人合一思维模式进行了全面分析。指出司空图《诗品》的思维模式遵循了中国古代由诗歌品阶、天时、时律、时历等形成的系统的天人合一模式，是典型的中国思维。     

素质拓展探索——建立数学教学新模式

本文简述建立数学教学新模式的必要性;论述了知识、能力、品质、方法之间的辨证关 系;提出了“知识、能力、品质”相结合的教学模式和一定的方法。     

Statistical Analyses and Modelling of the Mixing Process of Euro Coins in Germany and Europe

This paper reports on the mixing of Euro coins from different countries of origin in Europe, which started on 1 January 2002. There is an interesting conclusion: that the mobility of small and large denominations is different. The long‐term behaviour of the mixing process is studied using a simple deterministic model and data from Germany, France and the Netherlands. The analysis leads to predictions about the future progress of the mixing process.     

高师技法课改革的专业特殊性与科学性

本文从高师技法课(声乐、钢琴)教学改革的大潮中,提出了教学改革中应注意专业的特殊性和科学性,阐述了教学改革应遵循的基本原则以及合理的课型模式。     

Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

MAS环境下实现Agent交互协作的关键技术

讨论了MAS环境下实现Agent交互协作的关键性问题。在分析Agent协同设计目标的基础上,将遗传算法应用于子任务的调度,提高了Agent协同工作的效率。应用Agent的通信语言建立了一个基于知识查询与操纵语言的Agent通信模型,通过引入Agent位置追踪和Agent消息缓存机制解决了Agent移动过程中遇到的位置追踪和通信失效问题。     

素描教学改革新探

素描是培养造型基本功的一种手段 ,是一切造型艺术的基础。本文针对在教学过程中学生们对素描学科缺乏正确的认识 ,观念上产生误区 ,学习兴趣不浓的现象 ,谈了一些自己的教学经验 ,着重探讨了几点有效的教学途径 ,使素描教学更加适应时代的需要和发展     

反语的复现性--论认知语用学的反语观

本文从反语的复现性视角探讨了认知语用学的反语观,并将之与古典修辞语义学和Grice的会话含义理论的反语观作了对比分析,指出视反语为对非说话人的思想的复现和二级释解的认知语用学理论较有说服力地阐释了反语的本质特征和语用机制,弥补了传统语义学和语用学的反语现的不足。     

简论知识经济时代创新人才的继续教育培训模式

随着以科技创新为主要特征的知识经济时代的来临 ,继续教育要适应现代社会发展的需要 ,培养具有创新意识、创新能力的高素质人才 ,必须在教育观念、培养目标、教学内容、教学方法、教学手段、师资队伍等方面进行改革和创新 ,探索出适应知识经济时代需要的创新人才继续教育培训模式。