高薪养廉的必要性和约束条件分析

文章首先从政府和公务员之间的委托代理关系、人力资本的消耗和补偿、历史经验三个方面论述了高薪养廉的必要性 ;其次 ,分析了高薪养廉的约束条件 ;最后得出结论 ,高薪只是养廉的必要条件 ,但并非充分条件。它的真正实行 ,不但需要生产力发展的经济基础 ,而且还需要收入分配制度的改革、法律监督机制的健全、官僚机构的自身完善     

Markov chain Monte Carlo methods for high dimensional inversion in remote sensing

Summary.  We discuss the inversion of the gas profiles (ozone, NO₃, NO₂, aerosols and neutral density) in the upper atmosphere from the spectral occultation measurements. The data are produced by the 'Global ozone monitoring of occultation of stars' instrument on board the Envisat satellite that was launched in March 2002. The instrument measures the attenuation of light spectra at various horizontal paths from about 100 km down to 10–20 km. The new feature is that these data allow the inversion of the gas concentration height profiles. A short introduction is given to the present operational data management procedure with examples of the first real data inversion. Several solution options for a more comprehensive statistical inversion are presented. A direct inversion leads to a non-linear model with hundreds of parameters to be estimated. The problem is solved with an adaptive single-step Markov chain Monte Carlo algorithm. Another approach is to divide the problem into several non-linear smaller dimensional problems, to run parallel adaptive Markov chain Monte Carlo chains for them and to solve the gas profiles in repetitive linear steps. The effect of grid size is discussed, and we present how the prior regularization takes the grid size into account in a way that effectively leads to a grid-independent inversion.     

大学生主体性德育教学初探

本文拟在探讨如何把以人为本的方针科学地贯彻落实到高校德育教学中,探索在新的历史条件下高校推行大学生主体性德育教学方法的可行性,为进一步揭示高校德育教学的发展规律,提高高校德育教学的科学性、针对性、实效性提供可资借鉴方法。     

论保证高职教育质量的途径与对策

高职的教育质量问题为人们所关注。目前 ,在高职教育中存在着一些不利于提高教育质量的问题 ,本文分析了这些问题 ,并提出了相应的对策。     

A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

高宽课程一日常规本土化的“症状”分析

高宽课程一日常规是幼儿一天活动的顺序,因其支持幼儿的主动性发展顺应了各国教育改革的潮流而备受推崇。但其本土化在教育实践中出现了教师没能领悟到高宽课程理念的精髓、在实践中过于注重形式、本土化探索的积极性不高等方面的“症状”。本文从文化、园长、教师和家长四个方面对上述“症状”进行了“病源”分析。最后提出在移植高宽课程一日常规时应充分考虑到文化差异、强化对高宽课程的深入研究、加强师资培训,搭建师资培训平台、重视园长培训,提供宽松的教育环境、加强家园合作,获得家长支持等五条建议,以求“对症治疗”,使高宽课程一日常规为中国学前教育事业发展提供有益的借鉴。     

Multilevel maximum likelihood estimation with application to covariance matrices

The asymptotic variance of the maximum likelihood estimate is proved to decrease when the maximization is restricted to a subspace that contains the true parameter value. Maximum likelihood estimation allows a systematic fitting of covariance models to the sample, which is important in data assimilation. The hierarchical maximum likelihood approach is applied to the spectral diagonal covariance model with different parameterizations of eigenvalue decay, and to the sparse inverse covariance model with specified parameter values on different sets of nonzero entries. It is shown computationally that using smaller sets of parameters can decrease the sampling noise in high dimension substantially.     

Using In Vitro High‐Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards

Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high‐throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline‐based meta‐regression can be used to integrate data across multiple assay replicates to generate a concentration–response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk‐specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta‐regression, may allow risk assessors to identify points of departure and risk‐specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods.     

初中起点幼师大学生历史课过度教学现象探析

一般而言，历史课及其任课教师是比较受初中起点幼师大学生欢迎的。与此同时，历史课教学中也时常不经意间在教学内容安排、教学方法运用和教学观点表达等方面出现过度教学现象。学生主体地位的异化，教学过程把控失当和教学反思的缺位，是造成过度教学的主要原因。消除过度教学现象的对策主要是坚持教学过程中学生的主体地位，掌握教学有度的艺术和重视教学反思。     

高强混凝土高温性能研究进展

对近年来高强混凝土高温性能的研究成果进行了综述与分析,包括热工性、高温下和高温后力学性能以及高强高性能混凝土的爆裂性能。其中,高强混凝土热工性能方面的研究成果较少且研究结果离散性较大;高强混凝土力学性能方面的研究主要集中于抗压强度、抗拉强度、变形性能、弹性模量、泊松比、应力 应变关系等,而对高强混凝土结构、构件高温力学性能和温度场分析方面的研究较少;高强高性能混凝土爆裂方面的研究多集中于爆裂规律和爆裂抑制措施,对爆裂机理和微观结构的研究较少。本文分别从3个方面指出了高强混凝土高温性能研究中存在的问题和今后的研究方向,为深入研究高强混凝土的高温性能提供参考。